PLXND1

Plexin D1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3H6N

Identifiers

PLXND1 ; PLEXD1

External IDs

OMIM: 604282 MGI: 2154244 HomoloGene: 22866 GeneCards: PLXND1 Gene

Gene ontology
Molecular function	• protein binding • semaphorin receptor activity • protein domain specific binding
Cellular component	• intracellular • plasma membrane • integral component of plasma membrane • lamellipodium
Biological process	• angiogenesis • patterning of blood vessels • axon guidance • synapse assembly • regulation of cell migration • positive regulation of protein binding • endothelial cell migration • regulation of angiogenesis • dichotomous subdivision of terminal units involved in salivary gland branching • semaphorin-plexin signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000004399

ENSMUSG00000030123

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
129.27 – 129.33 Mb

Chr 6:
115.95 – 116 Mb

PubMed search

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.^[1]^[2]

References

↑ van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018.
↑ "Entrez Gene: PLXND1 plexin D1".

Further reading

Ishikawa K, Nagase T, Suyama M et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Tamagnone L, Artigiani S, Chen H et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gitler AD, Lu MM, Epstein JA (2004). "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.". Dev. Cell 7 (1): 107–16. doi:10.1016/j.devcel.2004.06.002. PMID 15239958.
van der Zwaag B, Verzijl HT, Wichers KH et al. (2004). "Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients.". Pediatr. Neurol. 31 (2): 114–8. doi:10.1016/j.pediatrneurol.2004.02.004. PMID 15301830.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.