PLXNB1
Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[1][2][3]
Function
Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[4] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[5]
Interactions
PLXNB1 has been shown to interact with ARHGEF12,[6] Rnd1[7] and ARHGEF11.[6][7][8][9]
References
- ↑ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S et al. (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
- ↑ Vikis HG, Li W, He Z, Guan KL (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A 97 (23): 12457–62. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813.
- ↑ "Entrez Gene: PLXNB1 plexin B1".
- ↑ Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF.". FEBS Letters 529 (2-3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594.
- ↑ Basile JR, Afkhami T, Gutkind JS (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.". Molecular and Cellular Biology 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703.
- ↑ 6.0 6.1 Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M et al. (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
- ↑ 7.0 7.1 Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
- ↑ Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
- ↑ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
Further reading
- Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
- Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
- Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
- Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
- Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
- Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12085–90. doi:10.1073/pnas.142433199. PMC 129402. PMID 12196628.
- Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D et al. (2002). "The semaphorin 4D receptor controls invasive growth by coupling with Met". Nat. Cell Biol. 4 (9): 720–4. doi:10.1038/ncb843. PMID 12198496.
- Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M et al. (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.
- Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes". Blood 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.
- Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW et al. (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
- Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
- Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
- Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
- Swiercz JM, Kuner R, Offermanns S (2004). "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2". J. Cell Biol. 165 (6): 869–80. doi:10.1083/jcb.200312094. PMC 2172401. PMID 15210733.
- Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science 305 (5685): 862–5. doi:10.1126/science.1097545. PMID 15297673.
- Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1". Blood 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.