PLK3

Polo-like kinase 3

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4B6L

Identifiers

Symbols

PLK3 ; CNK; FNK; PRK

External IDs

OMIM: 602913 MGI: 109604 HomoloGene: 20865 IUPHAR: 2170 ChEMBL: 4897 GeneCards: PLK3 Gene

EC number

2.7.11.21

Gene ontology
Molecular function	• p53 binding • protein serine/threonine kinase activity • protein binding • ATP binding
Cellular component	• nucleus • nucleolus • cytoplasm • Golgi stack • centrosome • dendrite • neuronal cell body
Biological process	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • mitotic S phase • G2/M transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • response to reactive oxygen species • cytokinesis • protein phosphorylation • apoptotic process • response to osmotic stress • cellular response to DNA damage stimulus • mitotic cell cycle checkpoint • endomitotic cell cycle • response to radiation • cytoplasmic microtubule organization • negative regulation of apoptotic process • protein kinase B signaling • regulation of cell division • Golgi disassembly • positive regulation of intracellular protein transport • positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
45.27 – 45.27 Mb

Chr 4:
117.13 – 117.13 Mb

PubMed search

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.^[1]^[2]

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.^[1]

Interactions

PLK3 has been shown to interact with:

References

↑ 1.0 1.1 "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)".
↑ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R et al. (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
↑ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
↑ 4.0 4.1 Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y et al. (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661.
↑ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C et al. (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.

Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R et al. (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627.
Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512.
Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B et al. (1997). "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): 28646–51. doi:10.1074/jbc.272.45.28646. PMID 9353331.
Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092.
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites". Genes Dev. 14 (3): 289–300. PMC 316358. PMID 10673501.
Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J et al. (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer 27 (3): 332–6. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID 10679924.
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. doi:10.1073/pnas.190030497. PMC 27034. PMID 10973490.
Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.
Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O et al. (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature 411 (6833): 102–7. doi:10.1038/35075107. PMID 11333986.
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C et al. (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930.
Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID 11709713.
Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain". J. Biol. Chem. 277 (22): 19389–95. doi:10.1074/jbc.M200822200. PMID 11901158.
Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA et al. (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase". Mol. Cell 9 (3): 515–25. doi:10.1016/S1097-2765(02)00473-2. PMID 11931760.
Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F et al. (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity". Mol. Cell. Biol. 22 (10): 3450–9. doi:10.1128/MCB.22.10.3450-3459.2002. PMC 133784. PMID 11971976.
Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y et al. (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661.
Tsvetkov L, Xu X, Li J, Stern DF (2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody". J. Biol. Chem. 278 (10): 8468–75. doi:10.1074/jbc.M211202200. PMID 12493754.
Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE et al. (2003). "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2". Cell Cycle 1 (6): 424–9. doi:10.4161/cc.1.6.271. PMID 12548019.
Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation". Oncogene 23 (15): 2658–63. doi:10.1038/sj.onc.1207425. PMID 14968113.

PLK3

Function

Interactions

References

Further reading