PLCD4

Phospholipase C, delta 4

Identifiers

PLCD4 ; MGC12837

External IDs

OMIM: 605939 MGI: 107469 HomoloGene: 88782 IUPHAR: 1411 ChEMBL: 5104 GeneCards: PLCD4 Gene

Gene ontology
Molecular function	• phosphatidylinositol phospholipase C activity • signal transducer activity • calcium ion binding
Cellular component	• nucleus • endoplasmic reticulum • membrane
Biological process	• acrosome reaction • lipid catabolic process • intracellular signal transduction • phosphatidylinositol metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000115556

ENSMUSG00000026173

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
219.47 – 219.5 Mb

Chr 1:
74.54 – 74.57 Mb

PubMed search

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.^[1]^[2]^[3]

References

↑ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta4 gene (PLCD4) to human chromosome band 2q35 by fluorescence in situ hybridization". Cytogenet Cell Genet 87 (3–4): 254–5. doi:10.1159/000015437. PMID 10702683.
↑ Ghosh S, Pawelczyk T, Lowenstein JM (Jun 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expr Purif 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
↑ "Entrez Gene: PLCD4 phospholipase C, delta 4".

Further reading

Cefai D, Debre P, Kaczorek M et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Zauli G, Previati M, Caramelli E et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mayne M, Bratanich AC, Chen P et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
Ananthanarayanan B, Das S, Rhee SG et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lee SB, Várnai P, Balla A et al. (2004). "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme". J. Biol. Chem. 279 (23): 24362–71. doi:10.1074/jbc.M312772200. PMID 15037625.
Leung DW, Tompkins C, Brewer J et al. (2004). "Phospholipase C δ-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells". Mol. Cancer 3: 15. doi:10.1186/1476-4598-3-15. PMC 420486. PMID 15140260.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chae SW, Kim JM, Yun YP et al. (2007). "Identification and analysis of the promoter region of the human PLC-delta4 gene". Mol. Biol. Rep. 34 (2): 69–77. doi:10.1007/s11033-006-9014-x. PMID 17394098.