PLCD1

Phospholipase C, delta 1

PDB rendering based on 1djg.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1djg, 1djh, 1dji, 1djw, 1djx, 1djy, 1djz, 1mai, 1qas, 1qat, 2isd

Identifiers

Symbols

PLCD1 ; NDNC3; PLC-III

External IDs

OMIM: 602142 MGI: 97614 HomoloGene: 21252 IUPHAR: 1409 ChEMBL: 3727 GeneCards: PLCD1 Gene

EC number

3.1.4.11

Gene ontology
Molecular function	• phosphatidylinositol phospholipase C activity • signal transducer activity • calcium ion binding • GTPase activating protein binding
Cellular component	• cytoplasm • cytosol • plasma membrane • extracellular vesicular exosome
Biological process	• angiogenesis • phospholipid metabolic process • lipid catabolic process • intracellular signal transduction • regulation of cell proliferation • inositol phosphate metabolic process • small molecule metabolic process • labyrinthine layer blood vessel development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
38.05 – 38.07 Mb

Chr 9:
119.07 – 119.09 Mb

PubMed search

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene.^[1]^[2] PLCd1 is essential to maintain homeostasis of the skin.

References

↑ Ishikawa S, Takahashi T, Ogawa M, Nakamura Y (Nov 1997). "Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3". Cytogenet Cell Genet 78 (1): 58–60. doi:10.1159/000134629. PMID 9345909.
↑ "Entrez Gene: PLCD1 phospholipase C, delta 1".

Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+.". J. Cell. Biochem. 97 (2): 233–43. doi:10.1002/jcb.20677. PMID 16240320.
Cefai D, Debre P, Kaczorek M et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
Zauli G, Previati M, Caramelli E et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
Cheng HF, Jiang MJ, Chen CL et al. (1995). "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis.". J. Biol. Chem. 270 (10): 5495–505. doi:10.1074/jbc.270.10.5495. PMID 7890667.
Ghosh S, Pawelczyk T, Lowenstein JM (1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties.". Protein Expr. Purif. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
Park ES, Won JH, Han KJ et al. (1998). "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector.". Biochem. J. 331 (1): 283–9. PMC 1219350. PMID 9512491.
Shimohama S, Kamiya S, Fujii M et al. (1998). "Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function.". Biochem. Biophys. Res. Commun. 245 (3): 722–8. doi:10.1006/bbrc.1998.8307. PMID 9588182.
Mayne M, Bratanich AC, Chen P et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3-4): 184–92. doi:10.1159/000026336. PMID 9730685.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
Nash MS, Young KW, Willars GB et al. (2001). "Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.". Biochem. J. 356 (Pt 1): 137–42. doi:10.1042/0264-6021:3560137. PMC 1221821. PMID 11336645.
Ananthanarayanan B, Das S, Rhee SG et al. (2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms.". J. Biol. Chem. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.
Keshamouni VG, Mattingly RR, Reddy KB (2002). "Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta.". J. Biol. Chem. 277 (25): 22558–65. doi:10.1074/jbc.M202351200. PMID 11960991.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Guo Y, Philip F, Scarlata S (2003). "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site.". J. Biol. Chem. 278 (32): 29995–30004. doi:10.1074/jbc.M301438200. PMID 12761218.
Caprini M, Gomis A, Cabedo H et al. (2003). "GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity.". EMBO J. 22 (12): 3004–14. doi:10.1093/emboj/cdg294. PMC 162146. PMID 12805215.
Kim JY, Kim H, Lee SG et al. (2003). "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.". Biochem. Biophys. Res. Commun. 310 (3): 904–9. doi:10.1016/j.bbrc.2003.09.100. PMID 14550290.

External links

WikiGenes entry for PLCD1

PDB gallery

1djg: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM

1djh: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM

1dji: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH CALCIUM

1djw: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2-METHYLENE-1,2-CYCLIC-MONOPHOSPHONATE

1djx: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-1,4,5-TRISPHOSPHATE

1djy: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-2,4,5-TRISPHOSPHATE

1djz: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH INOSITOL-4,5-BISPHOSPHATE

1mai: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE

1qas: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1

1qat: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA COMPLEX WITH SAMARIUM (III) CHLORIDE

2isd: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT

PLCD1

See also

References

Further reading

External links