PLCB3

Phospholipase C, beta 3 (phosphatidylinositol-specific)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolPLCB3
External IDsOMIM: 600230 MGI: 104778 HomoloGene: 47960 IUPHAR: 1405 ChEMBL: 5449 GeneCards: PLCB3 Gene
EC number3.1.4.11
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez533118797
EnsemblENSG00000149782ENSMUSG00000024960
UniProtQ01970P51432
RefSeq (mRNA)NM_000932NM_001290349
RefSeq (protein)NP_000923NP_001277278
Location (UCSC)Chr 11:
64.02 – 64.04 Mb		Chr 19:
6.95 – 6.97 Mb
PubMed search

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[1][2]

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[3]

References

  1. ↑ Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B et al. (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81. doi:10.1093/hmg/3.10.1775. PMID 7849701. Check date values in: |year= / |date= mismatch (help)
  2. ↑ "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)".
  3. ↑ Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH et al. (June 2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.

Further reading

  • Carozzi AJ, Kriz RW, Webster C, Parker PJ (1992). "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9. doi:10.1111/j.1432-1033.1992.tb17450.x. PMID 1333955.
  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D et al. (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
  • Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E et al. (1995). "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics 26 (3): 467–72. doi:10.1016/0888-7543(95)80164-H. PMID 7607669. Vancouver style error (help)
  • Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR (1995). "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene". Biochem. Biophys. Res. Commun. 212 (1): 190–5. doi:10.1006/bbrc.1995.1955. PMID 7612006.
  • Sinke RJ, Geurts van Kessel AG (1995). "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics 25 (2): 568–9. doi:10.1016/0888-7543(95)80060-Y. PMID 7789993.
  • Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
  • Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
  • Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A (1998). "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta 1393 (1): 173–8. doi:10.1016/s0005-2760(98)00074-5. PMID 9714794.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3-4): 184–92. doi:10.1159/000026336. PMID 9730685.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
  • Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH et al. (2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.
  • Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.
  • Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
  • Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617.
  • Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B (2001). "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31. doi:10.1006/bbrc.2001.4329. PMID 11178984. Vancouver style error (help)
  • Xia C, Bao Z, Yue C, Sanborn BM, Liu M (2001). "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases". J. Biol. Chem. 276 (23): 19770–7. doi:10.1074/jbc.M006266200. PMID 11278298.
  • Yue C, Sanborn BM (2001). "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1-2): 149–56. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.