PLCB1

Phospholipase C, beta 1 (phosphoinositide-specific)

Identifiers

PLCB1 ; EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B

External IDs

OMIM: 607120 MGI: 97613 HomoloGene: 22876 IUPHAR: 1403 ChEMBL: 4034 GeneCards: PLCB1 Gene

3.1.4.11

Gene ontology
Molecular function	• phosphatidylinositol phospholipase C activity • signal transducer activity • GTPase activator activity • calcium ion binding • calmodulin binding • lamin binding • phosphatidylinositol-4,5-bisphosphate binding • enzyme binding • protein homodimerization activity
Cellular component	• nuclear chromatin • nucleus • cytoplasm • cytosol • nuclear speck • nuclear membrane • extracellular vesicular exosome
Biological process	• G2/M transition of mitotic cell cycle • signal transduction • G-protein coupled acetylcholine receptor signaling pathway • glutamate receptor signaling pathway • synaptic transmission • memory • regulation of G-protein coupled receptor protein signaling pathway • lipid catabolic process • cerebral cortex development • positive regulation of interleukin-12 production • intracellular signal transduction • interleukin-12-mediated signaling pathway • interleukin-15-mediated signaling pathway • positive regulation of embryonic development • positive regulation of GTPase activity • inositol phosphate metabolic process • small molecule metabolic process • fat cell differentiation • positive regulation of myoblast differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of JNK cascade • phosphatidylinositol metabolic process • insulin-like growth factor receptor signaling pathway • positive regulation of developmental growth • activation of meiosis involved in egg activation • interleukin-1-mediated signaling pathway • regulation of fertilization • positive regulation of G1/S transition of mitotic cell cycle • positive regulation of acrosome reaction • negative regulation of monocyte extravasation • positive regulation of CD24 biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
8.11 – 8.95 Mb

Chr 2:
134.79 – 135.48 Mb

PubMed search

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

PLCB1 has been shown to interact with TRPM7.^[4]

Pathology

Homozygous PLCB1 deletion is associated with malignant migrating partial seizures in infancy.^[5]

References

↑ Peruzzi D, Calabrese G, Faenza I, Manzoli L, Matteucci A, Gianfrancesco F et al. (Jun 2000). "Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1)". Biochim. Biophys. Acta 1484 (2-3): 175–82. doi:10.1016/s1388-1981(00)00012-3. PMID 10760467. CS1 maint: Date and year (link)
↑ Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (Jan 2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617. Check date values in: |year= / |date= mismatch (help)
↑ 3.0 3.1 "Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)".
↑ Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. CS1 maint: Date and year (link)
↑ Poduri A, Chopra SS, Neilan EG, Elhosary PC, Kurian MA, Meyer E et al. (2012). "Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy". Epilepsia 53 (8): e146–50. doi:10.1111/j.1528-1167.2012.03538.x. PMC 3851296. PMID 22690784.

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PLCB1

Function

Interactions

Pathology

References

Further reading