PLAU

Plasminogen activator, urokinase
PDB rendering based on 1c5w.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1C5W, 1C5X, 1C5Y, 1C5Z, 1EJN, 1F5K, 1F5L, 1F92, 1FV9, 1GI7, 1GI8, 1GI9, 1GJ7, 1GJ8, 1GJ9, 1GJA, 1GJB, 1GJC, 1GJD, 1KDU, 1LMW, 1O3P, 1O5A, 1O5B, 1O5C, 1OWD, 1OWE, 1OWH, 1OWI, 1OWJ, 1OWK, 1SC8, 1SQA, 1SQO, 1SQT, 1U6Q, 1URK, 1VJ9, 1VJA, 1W0Z, 1W10, 1W11, 1W12, 1W13, 1W14, 2FD6, 2I9A, 2I9B, 2NWN, 2O8T, 2O8U, 2O8W, 2R2W, 2VIN, 2VIO, 2VIP, 2VIQ, 2VIV, 2VIW, 2VNT, 3BT1, 3BT2, 3IG6, 3KGP, 3KHV, 3KID, 3M61, 3MHW, 3MWI, 3OX7, 3OY5, 3OY6, 3PB1, 3QN7, 3U73, 4DVA, 4DW2, 4FU7, 4FU8, 4FU9, 4FUB, 4FUC, 4FUD, 4FUE, 4FUF, 4FUG, 4FUH, 4FUI, 4FUJ, 4GLY, 4H42, 4JK5, 4JK6, 4JNI, 4JNL, 4K24, 4MNV, 4MNW, 4MNX, 4MNY
Identifiers
Symbols	PLAU ; ATF; BDPLT5; QPD; UPA; URK; u-PA
External IDs	OMIM: 191840 MGI: 97611 HomoloGene: 55670 IUPHAR: 2393 ChEMBL: 3286 GeneCards: PLAU Gene
EC number	3.4.21.73
Gene ontology Molecular function • serine-type endopeptidase activity • protein binding Cellular component • extracellular region • extracellular space • plasma membrane • cell surface • extracellular vesicular exosome Biological process • response to hypoxia • proteolysis • chemotaxis • signal transduction • blood coagulation • regulation of receptor activity • smooth muscle cell migration • regulation of smooth muscle cell migration • regulation of cell adhesion mediated by integrin • regulation of cell proliferation • fibrinolysis • regulation of wound healing • regulation of smooth muscle cell-matrix adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5328	18792
Ensembl	ENSG00000122861	ENSMUSG00000021822
UniProt	P00749	P06869
RefSeq (mRNA)	NM_001145031	NM_008873
RefSeq (protein)	NP_001138503	NP_032899
Location (UCSC)	Chr 10: 75.67 – 75.68 Mb	Chr 14: 20.84 – 20.84 Mb
PubMed search

Urokinase-type plasminogen activator is an enzyme that in humans is encoded by the PLAU gene.^[1]

Function

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.^[2]

Interactions

PLAU has been shown to interact with Protein C inhibitor.^[3][4]

References

Further reading

PDB gallery 1c5w: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR  1c5x: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR  1c5y: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR  1c5z: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR  1ejn: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX  1f5k: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-BENZAMIDINE COMPLEX  1f5l: UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX  1f92: UROKINASE PLASMINOGEN ACTIVATOR B CHAIN-UKI-1D COMPLEX  1fv9: Crystal structure of human microurokinase in complex with 2-amino-5-hydroxy-benzimidazole  1gi7: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE  1gi8: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE  1gi9: A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE  1gj7: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gj8: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gj9: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gja: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gjb: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gjc: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1gjd: ENGINEERING INHIBITORS HIGHLY SELECTIVE FOR THE S1 SITES OF SER190 TRYPSIN-LIKE SERINE PROTEASE DRUG TARGETS  1kdu: SEQUENTIAL 1H NMR ASSIGNMENTS AND SECONDARY STRUCTURE OF THE KRINGLE DOMAIN FROM UROKINASE  1lmw: LMW U-PA STRUCTURE COMPLEXED WITH EGRCMK (GLU-GLY-ARG CHLOROMETHYL KETONE)  1o3p: Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors  1o5a: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)  1o5b: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)  1o5c: Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)  1owd: Substituted 2-Naphthamidine inhibitors of urokinase  1owe: Substituted 2-Naphthamidine inhibitors of urokinase  1owh: Substituted 2-Naphthamidine Inhibitors of Urokinase  1owi: Substituted 2-Naphthamidine Inhibitors of Urokinase  1owj: Substituted 2-Naphthamidine Inhibitors of Urokinase  1owk: Substituted 2-Naphthamidine Inhibitors of Urokinase  1sc8: Urokinase Plasminogen Activator B-Chain-J435 Complex  1sqa: Substituted 2-Naphthamidine Inhibitors of Urokinase  1sqo: Substituted 2-Naphthamidine Inhibitors of Urokinase  1sqt: Substituted 2-Naphthamidine Inhibitors of Urokinase  1u6q: Substituted 2-Naphthamadine inhibitors of Urokinase  1urk: SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR  1vj9: Urokinase Plasminogen Activator B-Chain-JT464 Complex  1vja: Urokinase Plasminogen Activator B-Chain-JT464 Complex  2fd6: Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A  2i9a: Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)  2i9b: Crystal structure of ATF-urokinase receptor complex