PJA2

Praja ring finger 2, E3 ubiquitin protein ligase

Identifiers

PJA2 ; Neurodap1; RNF131

External IDs

MGI: 2159342 HomoloGene: 32233 GeneCards: PJA2 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • zinc ion binding • ligase activity • protein kinase A catalytic subunit binding • protein kinase A regulatory subunit binding
Cellular component	• Golgi membrane • cytoplasm • endoplasmic reticulum membrane • plasma membrane • postsynaptic density • cell junction • postsynaptic membrane
Biological process	• long-term memory • regulation of protein kinase A signaling • protein ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000198961

ENSMUSG00000024083

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
108.67 – 108.75 Mb

Chr 17:
64.28 – 64.33 Mb

PubMed search

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene.^[1]

Interactions

PJA2 has been shown to interact with UBE2D2.^[2]

References

↑ "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".
↑ Yu, Ping; Chen Yiwang; Tagle Danilo A; Cai Tao (Jun 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics (United States) 79 (6): 869–74. doi:10.1006/geno.2002.6770. ISSN 0888-7543. PMID 12036302.

Further reading

Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu P, Chen Y, Tagle DA, Cai T (2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.". Genomics 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
Sasaki A, Masuda Y, Iwai K et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Ishikawa K, Nagase T, Nakajima D et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Mishra L, Tully RE, Monga SP et al. (1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development.". Oncogene 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Miyake T, Gahara Y et al. (1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse.". J. Neurosci. 15 (7 Pt 2): 5238–48. PMID 7623148.