PIK3R2

Phosphoinositide-3-kinase, regulatory subunit 2 (beta)

Rendering based on PDB 2KT1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPIK3R2 ; MPPH; P85B; p85; p85-BETA
External IDsOMIM: 603157 MGI: 1098772 HomoloGene: 3687 IUPHAR: 2504 ChEMBL: 4437 GeneCards: PIK3R2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez529618709
EnsemblENSG00000105647ENSMUSG00000031834
UniProtO00459O08908
RefSeq (mRNA)NM_005027NM_008841
RefSeq (protein)NP_005018NP_032867
Location (UCSC)Chr 19:
18.26 – 18.28 Mb		Chr 8:
70.77 – 70.78 Mb
PubMed search

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.[1][2]

Interactions

PIK3R2 has been shown to interact with FYN,[3] HER2/neu,[3] Epidermal growth factor,[3] Cbl gene,[4][5] PIK3CD,[6] CRKL[7] and Macrophage colony-stimulating factor.[3]

References

  1. ↑ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (May 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene 7 (4): 789–93. PMID 1314371.
  2. ↑ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)".
  3. ↑ 3.0 3.1 3.2 3.3 Gout, I; Dhand R; Panayotou G; Fry M J; Hiles I; Otsu M; Waterfield M D (Dec 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. (ENGLAND) 288 (2): 395–405. ISSN 0264-6021. PMC 1132024. PMID 1334406.
  4. ↑ Lin, H; Martelli M P; Bierer B E (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". Int. Immunol. (England) 13 (1): 13–22. doi:10.1093/intimm/13.1.13. ISSN 0953-8178. PMID 11133830.
  5. ↑ Hartley, D; Meisner H; Corvera S (Aug 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". J. Biol. Chem. (UNITED STATES) 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. ISSN 0021-9258. PMID 7629144.
  6. ↑ Vanhaesebroeck, B; Welham M J; Kotani K; Stein R; Warne P H; Zvelebil M J; Higashi K; Volinia S; Downward J; Waterfield M D (Apr 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. ISSN 0027-8424. PMC 20722. PMID 9113989.
  7. ↑ Sattler, M; Salgia R; Shrikhande G; Verma S; Pisick E; Prasad K V; Griffin J D (Apr 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". J. Biol. Chem. (UNITED STATES) 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. ISSN 0021-9258. PMID 9092574.

Further reading

  • Lee C, Liu QH, Tomkowicz B et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
  • Gout I, Dhand R, Panayotou G et al. (1993). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.". Biochem. J. 288 (2): 395–405. PMC 1132024. PMID 1334406.
  • Carpenter CL, Duckworth BC, Auger KR et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver.". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051.
  • Truitt KE, Hicks CM, Imboden JB (1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.". J. Exp. Med. 179 (3): 1071–6. doi:10.1084/jem.179.3.1071. PMC 2191424. PMID 7509360.
  • Herbst R, Shearman MS, Jallal B et al. (1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro.". Biochemistry 34 (17): 5971–9. doi:10.1021/bi00017a026. PMID 7537096.
  • Craparo A, O'Neill TJ, Gustafson TA (1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.". J. Biol. Chem. 270 (26): 15639–43. doi:10.1074/jbc.270.26.15639. PMID 7541045.
  • He W, O'Neill TJ, Gustafson TA (1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.". J. Biol. Chem. 270 (40): 23258–62. doi:10.1074/jbc.270.40.23258. PMID 7559478.
  • Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.". J. Biol. Chem. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
  • Hartley D, Meisner H, Corvera S (1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl.". J. Biol. Chem. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144.
  • Pandey A, Lazar DF, Saltiel AR, Dixit VM (1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.". J. Biol. Chem. 269 (48): 30154–7. PMID 7982920.
  • August A, Dupont B (1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase.". Int. Immunol. 6 (5): 769–74. doi:10.1093/intimm/6.5.769. PMID 8080844.
  • Fukazawa T, Miyake S, Band V, Band H (1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.". J. Biol. Chem. 271 (24): 14554–9. doi:10.1074/jbc.271.24.14554. PMID 8662998.
  • Milani D, Mazzoni M, Borgatti P et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
  • Sattler M, Salgia R, Shrikhande G et al. (1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).". J. Biol. Chem. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.
  • Vanhaesebroeck B, Welham MJ, Kotani K et al. (1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
  • Briand G, Barbeau B, Tremblay M (1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.". Virology 228 (2): 171–9. doi:10.1006/viro.1996.8399. PMID 9123823.
  • Braunger J, Schleithoff L, Schulz AS et al. (1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.". Oncogene 14 (22): 2619–31. doi:10.1038/sj.onc.1201123. PMID 9178760.
  • Shepherd PR, Navé BT, Rincon J et al. (1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.". J. Biol. Chem. 272 (30): 19000–7. doi:10.1074/jbc.272.30.19000. PMID 9228082.
  • Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.