PHLDB2
| Pleckstrin homology-like domain, family B, member 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PHLDB2 ; LL5b; LL5beta | ||||||||||
| External IDs | OMIM: 610298 MGI: 2444981 HomoloGene: 17100 GeneCards: PHLDB2 Gene | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 90102 | 208177 | |||||||||
| Ensembl | ENSG00000144824 | ENSMUSG00000033149 | |||||||||
| UniProt | Q86SQ0 | Q8K1N2 | |||||||||
| RefSeq (mRNA) | NM_001134437 | NM_001252442 | |||||||||
| RefSeq (protein) | NP_001127909 | NP_001239371 | |||||||||
| Location (UCSC) | Chr 3: 111.45 – 111.7 Mb | Chr 16: 45.75 – 45.95 Mb | |||||||||
| PubMed search | |||||||||||
Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.[1][2]
Interactions
PHLDB2 has been shown to interact with FLNC.[1]
References
- ↑ 1.0 1.1 Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
- ↑ "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".
Further reading
- Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
- Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
- Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.