PHF12

PHD finger protein 12

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2L9S, 2LKM

Identifiers

PHF12 ; PF1

External IDs

MGI: 1924057 HomoloGene: 10841 GeneCards: PHF12 Gene

Gene ontology
Molecular function	• RNA polymerase II transcription corepressor activity • transcription corepressor binding • protein binding • zinc ion binding • phosphatidylinositol binding
Cellular component	• nucleus • nucleolus • Sin3 complex • transcriptional repressor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000109118

ENSMUSG00000037791

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
27.23 – 27.28 Mb

Chr 11:
77.98 – 78.03 Mb

PubMed search

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.^[1]^[2]

Interactions

PHF12 has been shown to interact with SIN3A.^[1]

References

↑ 1.0 1.1 Yochum GS, Ayer DE (Jun 2001). "Pf1, a Novel PHD Zinc Finger Protein That Links the TLE Corepressor to the mSin3A-Histone Deacetylase Complex". Mol Cell Biol 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
↑ "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

Nousiainen M; Silljé HH; Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA; Jedrychowski M; Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Nagase T; Kikuno R; Ishikawa K et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.