PFTK1

Cyclin-dependent kinase 14

Identifiers

CDK14 ; PFTAIRE1; PFTK1

External IDs

OMIM: 610679 MGI: 894318 HomoloGene: 7888 IUPHAR: 1967 ChEMBL: 6162 GeneCards: CDK14 Gene

Gene ontology
Molecular function	• cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding • cyclin binding
Cellular component	• cytoplasmic cyclin-dependent protein kinase holoenzyme complex • nucleus • cytoplasm • cytosol • plasma membrane
Biological process	• G2/M transition of mitotic cell cycle • protein phosphorylation • Wnt signaling pathway • cell division • regulation of cell cycle • regulation of canonical Wnt signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000058091

ENSMUSG00000028926

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
90.1 – 90.84 Mb

Chr 5:
4.8 – 5.42 Mb

PubMed search

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the PFTK1 gene.^[1]^[2]^[3]

Interactions

PFTK1 has been shown to interact with SEPT8.^[4]

References

↑ Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329.
↑ Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
↑ "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
↑ Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (China) 34 (4): 520–5. ISSN 0582-9879. PMID 12098780.

Further reading

Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1.". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (4): 520–5. PMID 12098780.
Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Gao Y, Jiang M, Yang T et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins.". Cell Res. 16 (6): 539–47. doi:10.1038/sj.cr.7310071. PMID 16775625.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Shu F, Lv S, Qin Y et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase.". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. doi:10.1073/pnas.0703327104. PMC 1890480. PMID 17517622.
Denoeud F, Kapranov P, Ucla C et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.