PDGFA

Platelet-derived growth factor alpha polypeptide

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3MJK

Identifiers

Symbols

PDGFA ; PDGF-A; PDGF1

External IDs

OMIM: 173430 MGI: 97527 HomoloGene: 32055 GeneCards: PDGFA Gene

Gene ontology
Molecular function	• platelet-derived growth factor receptor binding • protein binding • collagen binding • growth factor activity • protein homodimerization activity • protein heterodimerization activity • platelet-derived growth factor binding
Cellular component	• Golgi membrane • extracellular region • extracellular space • endoplasmic reticulum lumen • microvillus • cell surface • platelet alpha granule lumen
Biological process	• angiogenesis • response to hypoxia • cell activation • hair follicle development • positive regulation of mesenchymal cell proliferation • platelet degranulation • epidermal growth factor receptor signaling pathway • transforming growth factor beta receptor signaling pathway • cell-cell signaling • blood coagulation • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • response to wounding • embryo development • organ morphogenesis • response to inorganic substance • negative regulation of phosphatidylinositol biosynthetic process • negative regulation of platelet activation • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of smooth muscle cell migration • cell projection assembly • actin cytoskeleton organization • platelet activation • extracellular matrix organization • positive regulation of cell migration • positive regulation of protein autophosphorylation • response to estradiol • response to retinoic acid • regulation of actin cytoskeleton organization • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • Fc-epsilon receptor signaling pathway • wound healing • response to drug • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • skin development • innate immune response • positive regulation of DNA replication • platelet-derived growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • lung alveolus development • inner ear development • regulation of peptidyl-tyrosine phosphorylation • negative chemotaxis • positive regulation of cell division • positive regulation of protein kinase B signaling • regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling • positive regulation of ERK1 and ERK2 cascade • regulation of glomerular mesangial cell proliferation • regulation of DNA biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
0.54 – 0.56 Mb

Chr 5:
138.98 – 139 Mb

PubMed search

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.^[1]^[2]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.^[3]

References

↑ Stenman G, Rorsman F, Huebner K, Betsholtz C (Sep 1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet 60 (3–4): 206–7. doi:10.1159/000133337. PMID 1505216.
↑ Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S (Mar 1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science 243 (4892): 800–4. doi:10.1126/science.2536956. PMID 2536956.
↑ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide".

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Raines EW, Lane TF, Iruela-Arispe ML et al. (1992). "The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1281–5. doi:10.1073/pnas.89.4.1281. PMC 48433. PMID 1311092.
Andersson M, Ostman A, Bäckström G et al. (1992). "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF". J. Biol. Chem. 267 (16): 11260–6. PMID 1317862.
Rorsman F, Leveen P, Betsholtz C (1993). "Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites". Growth Factors 7 (3): 241–51. doi:10.3109/08977199209046928. PMID 1360804.
Wang Z, Lin XH, Qiu QQ, Deuel TF (1992). "Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease". J. Biol. Chem. 267 (24): 17022–31. PMID 1512241.
Bonthron D, Collins T, Grzeschik KH et al. (1992). "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite". Genomics 13 (2): 257–63. doi:10.1016/0888-7543(92)90240-S. PMID 1612586.
Takimoto Y, Wang ZY, Kobler K, Deuel TF (1991). "Promoter region of the human platelet-derived growth factor A-chain gene". Proc. Natl. Acad. Sci. U.S.A. 88 (5): 1686–90. doi:10.1073/pnas.88.5.1686. PMC 51089. PMID 1848007.
Fabisiak JP, Evans JN, Absher M et al. (1991). "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during remodeling". Chest 99 (3 Suppl): 52S–54S. doi:10.1378/chest.99.3_Supplement.52S. PMID 1997274.
Mendoza AE, Young R, Orkin SH, Collins T (1990). "Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2177–81. doi:10.1073/pnas.87.6.2177. PMC 53649. PMID 2315311.
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH (1989). "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 4917–21. doi:10.1073/pnas.86.13.4917. PMC 297526. PMID 2544881.
Rorsman F, Bywater M, Knott TJ et al. (1988). "Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins". Mol. Cell. Biol. 8 (2): 571–7. PMC 363182. PMID 2832727.
Beckmann MP, Betsholtz C, Heldin CH et al. (1988). "Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains". Science 241 (4871): 1346–9. doi:10.1126/science.2842868. PMID 2842868.
Bonthron DT, Morton CC, Orkin SH, Collins T (1988). "Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1492–6. doi:10.1073/pnas.85.5.1492. PMC 279797. PMID 3422746.
Tong BD, Auer DE, Jaye M et al. (1987). "cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains". Nature 328 (6131): 619–21. doi:10.1038/328619a0. PMID 3614363.
Collins T, Bonthron DT, Orkin SH (1987). "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain". Nature 328 (6131): 621–4. doi:10.1038/328621a0. PMID 3614364.
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Growth factors

Fibroblast

FGF receptor ligands:	FGF1/FGF2/FGF5 FGF3/FGF4/FGF6

KGF	FGF7/FGF10/FGF22 FGF8/FGF17/FGF18 FGF9/FGF16/FGF20

FGF homologous factors:	FGF11 FGF12 FGF13 FGF14

hormone-like:	FGF19 FGF21 FGF23

EGF-like domain

TGFβ pathway

TGF-β
- TGF-β1
- TGF-β2
- TGF-β3

Insulin-like

IGF-1
IGF-2

Platelet-derived

Vascular endothelial

VEGF-A
VEGF-B
VEGF-C
VEGF-D
PGF

Other

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

PDGFA

References

Further reading