PDE4C
| Phosphodiesterase 4C, cAMP-specific | |||||||||||||
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 Rendering based on PDB 1LXU. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PDE4C ; DPDE1 | ||||||||||||
| External IDs | OMIM: 600128 MGI: 99556 HomoloGene: 20256 IUPHAR: 1302 ChEMBL: 291 GeneCards: PDE4C Gene | ||||||||||||
| EC number | 3.1.4.53 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5143 | 110385 | |||||||||||
| Ensembl | ENSG00000105650 | ENSMUSG00000031842 | |||||||||||
| UniProt | Q08493 | Q3UEI1 | |||||||||||
| RefSeq (mRNA) | NM_000923 | NM_201607 | |||||||||||
| RefSeq (protein) | NP_000914 | NP_963901 | |||||||||||
| Location (UCSC) | Chr 19: 18.32 – 18.37 Mb | Chr 8: 70.72 – 70.75 Mb | |||||||||||
| PubMed search | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.[1]
Tissue localisation
PDE4C is predominantly found in peripheral tissues.[2]
References
- ↑ "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
- ↑ Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182.
Further reading
- Engels P, Sullivan M, Müller T, Lübbert H (1995). "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C).". FEBS Lett. 358 (3): 305–10. doi:10.1016/0014-5793(94)01460-I. PMID 7843419.
- Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369.
- Bolger G, Michaeli T, Martins T et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. PMC 364715. PMID 8413254.
- Obernolte R, Ratzliff J, Baecker PA et al. (1997). "Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis". Biochim. Biophys. Acta 1353 (3): 287–97. doi:10.1016/s0167-4781(97)00080-8. PMID 9349724.
- Owens RJ, Lumb S, Rees-Milton K et al. (1998). "Molecular cloning and expression of a human phosphodiesterase 4C". Cell. Signal. 9 (8): 575–85. doi:10.1016/S0898-6568(97)00072-7. PMID 9429761.
- Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal. 11 (10): 735–42. doi:10.1016/S0898-6568(99)00037-6. PMID 10574328.
- Zauli G, Milani D, Mirandola P et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
- Pérez-Torres S, Miró X, Palacios JM et al. (2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain". J. Chem. Neuroanat. 20 (3–4): 349–74. doi:10.1016/S0891-0618(00)00097-1. PMID 11207431.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Johnson JM, Castle J, Garrett-Engele P et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.