PCYT1A

Phosphate cytidylyltransferase 1, choline, alpha

PDB rendering based on 1peh.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1peh

Identifiers

PCYT1A ; CCTA; CT; CTA; CTPCT; PCYT1; SMDCRD

External IDs

OMIM: 123695 MGI: 88557 HomoloGene: 3680 GeneCards: PCYT1A Gene

Gene ontology
Molecular function	• choline-phosphate cytidylyltransferase activity • lipid binding • protein homodimerization activity
Cellular component	• endoplasmic reticulum membrane • cytosol • glycogen granule
Biological process	• phospholipid metabolic process • phosphatidylcholine biosynthetic process • CDP-choline pathway • small molecule metabolic process • glycerophospholipid biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000161217

ENSMUSG00000005615

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
195.94 – 196.01 Mb

Chr 16:
32.43 – 32.48 Mb

PubMed search

Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.^[1]^[2]

References

↑ Kalmar GB, Kay RJ, LaChance AC, Cornell RB (Nov 1994). "Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase". Biochim Biophys Acta 1219 (2): 328–34. doi:10.1016/0167-4781(94)90056-6. PMID 7918629.
↑ "Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha".

Further reading

Hunt AN, Normand CS, Postle AD (1990). "CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin.". Biochim. Biophys. Acta 1043 (1): 19–26. doi:10.1016/0005-2760(90)90105-7. PMID 2155660.
Vance JE, Vance DE (1988). "Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion?". J. Biol. Chem. 263 (12): 5898–909. PMID 2833521.
Weinhold PA, Feldman DA (1995). "Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein.". Arch. Biochem. Biophys. 318 (1): 147–56. doi:10.1006/abbi.1995.1215. PMID 7726555.
Johnson JE, Cornell RB (1994). "Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase.". Biochemistry 33 (14): 4327–35. doi:10.1021/bi00180a029. PMID 8155650.
Dunne SJ, Cornell RB, Johnson JE et al. (1996). "Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase.". Biochemistry 35 (37): 11975–84. doi:10.1021/bi960821. PMID 8810902.
Arnold RS, DePaoli-Roach AA, Cornell RB (1997). "Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes.". Biochemistry 36 (20): 6149–56. doi:10.1021/bi970023z. PMID 9166786.
Yang J, Wang J, Tseu I et al. (1997). "Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions.". Biochem. J. 325. ( Pt 1): 29–38. PMC 1218525. PMID 9224626.
Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant.". J. Biol. Chem. 274 (38): 26992–7001. doi:10.1074/jbc.274.38.26992. PMID 10480912.
Lagace TA, Miller JR, Ridgway ND (2002). "Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis.". Mol. Cell. Biol. 22 (13): 4851–62. doi:10.1128/MCB.22.13.4851-4862.2002. PMC 133913. PMID 12052891.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guenther MG, Yu J, Kao GD et al. (2003). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.
Xie M, Smith JL, Ding Z et al. (2004). "Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase.". J. Biol. Chem. 279 (27): 28817–25. doi:10.1074/jbc.M403311200. PMID 15069071.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Enaw JO, Zhu H, Yang W et al. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population.". BMC medicine 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928. PMID 17184542.

PDB gallery

1peh: NMR STRUCTURE OF THE MEMBRANE-BINDING DOMAIN OF CTP PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE, 10 STRUCTURES