PCTK3

Cyclin-dependent kinase 18

Identifiers

CDK18 ; PCTAIRE; PCTAIRE3; PCTK3

External IDs

OMIM: 169190 MGI: 97518 HomoloGene: 1949 IUPHAR: 1971 ChEMBL: 5316 GeneCards: CDK18 Gene

Gene ontology
Molecular function	• cyclin-dependent protein serine/threonine kinase activity • protein binding • ATP binding
Cellular component	• cellular_component
Biological process	• protein phosphorylation • regulation of cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000117266

ENSMUSG00000026437

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
205.47 – 205.5 Mb

Chr 1:
132.11 – 132.14 Mb

PubMed search

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the PCTK3 gene.^[1]^[2]

References

↑ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene 7 (11): 2249–58. PMID 1437147.
↑ "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Further reading

Meyerson M, Enders GH, Wu CL et al. (1992). "A family of human cdc2-related protein kinases.". EMBO J. 11 (8): 2909–17. PMC 556772. PMID 1639063.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes.". Genomics 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.". Gene 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.". J. Cell. Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease.". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195.
Wissing J, Jänsch L, Nimtz M et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.