PCLKC
| Cadherin-related family member 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CDHR2 ; PCDH24; PCLKC | ||||||||||||
| External IDs | MGI: 2687323 HomoloGene: 134510 GeneCards: CDHR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54825 | 268663 | |||||||||||
| Ensembl | ENSG00000074276 | ENSMUSG00000034918 | |||||||||||
| UniProt | Q9BYE9 | B9EJ32 | |||||||||||
| RefSeq (mRNA) | NM_001171976 | NM_001033364 | |||||||||||
| RefSeq (protein) | NP_001165447 | NP_001028536 | |||||||||||
| Location (UCSC) | Chr 5: 175.97 – 176.02 Mb | Chr 13: 54.7 – 54.74 Mb | |||||||||||
| PubMed search | |||||||||||||
Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[1][2][3]
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.[3]
Interactions
PCLKC has been shown to interact with MAST2.[2]
References
- ↑ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
- ↑ 2.0 2.1 Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
- ↑ 3.0 3.1 "Entrez Gene: PCLKC protocadherin LKC".
Further reading
- Yang LY, Wang W, Peng JX et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma.". World J. Gastroenterol. 10 (24): 3569–73. PMID 15534908.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.