PCDH18
| Protocadherin 18 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PCDH18 ; PCDH68L | ||||||||||||
| External IDs | OMIM: 608287 MGI: 1920423 HomoloGene: 10389 GeneCards: PCDH18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54510 | 73173 | |||||||||||
| Ensembl | ENSG00000189184 | ENSMUSG00000037892 | |||||||||||
| UniProt | Q9HCL0 | Q8VHR0 | |||||||||||
| RefSeq (mRNA) | NM_001300828 | NM_130448 | |||||||||||
| RefSeq (protein) | NP_001287757 | NP_569715 | |||||||||||
| Location (UCSC) | Chr 4: 138.44 – 138.45 Mb | Chr 3: 49.74 – 49.76 Mb | |||||||||||
| PubMed search | |||||||||||||
Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[1][2][3]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[3]
References
- ↑ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- ↑ Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
- ↑ 3.0 3.1 "Entrez Gene: PCDH18 protocadherin 18".
Further reading
- Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. PMID 10817752.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Homayouni R, Rice DS, Curran T (2002). "Disabled-1 interacts with a novel developmentally regulated protocadherin". Biochem. Biophys. Res. Commun. 289 (2): 539–47. doi:10.1006/bbrc.2001.5998. PMID 11716507.
- Nagase T, Kikuno R, Nakayama M et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.