PAPPA2

Pappalysin 2

Identifiers

PAPPA2 ; PAPP-A2; PAPP-E; PAPPE; PLAC3

External IDs

MGI: 3051647 HomoloGene: 10661 GeneCards: PAPPA2 Gene

Gene ontology
Molecular function	• metallopeptidase activity • zinc ion binding
Cellular component	• extracellular region • intracellular • membrane • extracellular vesicular exosome
Biological process	• regulation of cell growth • proteolysis • cell differentiation • cellular protein metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000116183

ENSMUSG00000073530

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
176.43 – 176.81 Mb

Chr 1:
158.71 – 158.98 Mb

PubMed search

Pappalysin-2 is a protein that in humans is encoded by the PAPPA2 gene.^[1]^[2]^[3]

References

↑ Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
↑ Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
↑ "Entrez Gene: PAPPA2 pappalysin 2".

Further reading

Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins.". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.". Placenta 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.