PABPC3

Poly(A) binding protein, cytoplasmic 3

PDB rendering based on 1g9l.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2D9P, 4IVE

Identifiers

Symbols

PABPC3 ; PABP3; PABPL3; tPABP

External IDs

OMIM: 604680 HomoloGene: 118007 GeneCards: PABPC3 Gene

Gene ontology
Molecular function	• nucleotide binding • poly(A) binding
Cellular component	• cytoplasm
Biological process	• mRNA metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_030979

n/a

RefSeq (protein)

NP_112241

n/a

Location (UCSC)

Chr 13:
25.67 – 25.67 Mb

n/a

PubMed search

n/a

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene.^[1]^[2]^[3]

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM]^[3]

References

↑ Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics 15 (1): 209–11. doi:10.1006/geno.1993.1037. PMID 8432538.
↑ Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet 105 (4): 347–53. doi:10.1007/s004390051113. PMC 1865476. PMID 10543404.
↑ 3.0 3.1 "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

Marques AC, Dupanloup I, Vinckenbosch N et al. (2006). "Emergence of young human genes after a burst of retroposition in primates.". PLoS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMC 1251493. PMID 16201836.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein.". Nucleic Acids Res. 29 (9): 1872–83. doi:10.1093/nar/29.9.1872. PMC 37253. PMID 11328870.
Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hoshino S, Imai M, Kobayashi T et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.

PDB gallery

1g9l: SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN

1jgn: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip2

1jh4: Solution structure of the C-terminal PABC domain of human poly(A)-binding protein in complex with the peptide from Paip1

2d9p: Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3

RNA-binding proteins

Butyrate response factor 1
Fragile X mental retardation protein
Rev
hu paraneoplastic encephalomyelitis antigens
mRNA cleavage and polyadenylation factors (Cleavage and polyadenylation specificity factor
Cleavage stimulation factor)
host factor 1 protein
Aconitase (ACO1
ACO2)
nuclear factor 90 proteins (ILF2)
Poly(A)-binding protein (PABPC1
PABPC3
PABPC4)
polypyrimidine tract-binding protein
ribonucleoprotein
RNA cap-binding protein (Cap binding complex
EIF4E
EIF4G1)
SMN complex proteins (SMN1
SMN2
DDX20)

Index of genetics

Description	Gene expression DNA replication cycle recombination repair binding proteins Transcription factors regulators nucleic acids RNA RNA binding proteins ribonucleoproteins repeated sequence modification Translation ribosome modification nexins Proteins domains Structure primary secondary tertiary quaternary

Disease	Replication and repair Transcription factor Transcription Translation

PABPC3

References

Further reading