Oxalobacter formigenes
| Oxalobacter formigenes | |
|---|---|
| Scientific classification | |
| Kingdom: | Bacteria |
| Phylum: | Proteobacteria |
| Order: | Burkholderiales |
| Family: | Oxalobacteraceae |
| Genus: | Oxalobacter |
| Species: | O. formigenes |
| Binomial name | |
| Oxalobacter formigenes | |
Oxalobacter formigenes is an oxalate-degrading anaerobic bacterium that colonizes the large intestine of numerous vertebrates, including humans. O. formigenes and humans share a beneficial symbiosis.
Quinolone, a broad-spectrum antibiotic, kills O. formigenes. If a person's gastrointestinal tract lacks this bacterium, and therefore lacks the primary source for the Oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some Vit B6 modulated partial metabolical degradation in the body, is excreted in the kidney where it precipitates with calcium forming calcium oxalate kidney stones.[1] [2] [3]
References
- ↑ (interim reference, describes two other studies)
- ↑ Pearle MS, Goldfarb DS, Assimos DG et al. (2014). "Medical management of kidney stones: AUA guideline.". J. Urol 192 (2): 316–324. doi:10.1016/j.juro.2014.05.006. PMID 24857648. Retrieved 26 December 2014.
- ↑ Siener R, Rangen U, Sidhu H et al. (2013). "The role of Oxalobacter formigenes colonization in calcium oxalate stone disease". Kidney Int 83 (June): 1144–9. doi:10.1038/ki.2013.104. PMID 23536130. Retrieved 26 December 2014.