OSTF1

Osteoclast stimulating factor 1

PDB rendering based on 1x2k.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1X2K, 1ZLM, 3EHQ, 3EHR

Identifiers

OSTF1 ; OSF; SH3P2; bA235O14.1

External IDs

OMIM: 610180 MGI: 700012 HomoloGene: 8227 GeneCards: OSTF1 Gene

Gene ontology
Molecular function	• protein binding • SH3 domain binding
Cellular component	• intracellular • cytoplasm • extracellular vesicular exosome
Biological process	• ossification • signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000134996

ENSMUSG00000024725

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
77.7 – 77.76 Mb

Chr 19:
18.58 – 18.63 Mb

PubMed search

Osteoclast-stimulating factor 1 is a protein that in humans is encoded by the OSTF1 gene.^[1]^[2]

References

↑ Reddy S, Devlin R, Menaa C, Nishimura R, Choi SJ, Dallas M, Yoneda T, Roodman GD (Apr 1999). "Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption". J Cell Physiol 177 (4): 636–45. doi:10.1002/(SICI)1097-4652(199812)177:4<636::AID-JCP14>3.0.CO;2-H. PMID 10092216.
↑ "Entrez Gene: OSTF1 osteoclast stimulating factor 1".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sparks AB, Hoffman NG, McConnell SJ et al. (1998). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nat. Biotechnol. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982.
Schaub R, Dupont B, Roodman GD et al. (2000). "Assignment of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 87–8. doi:10.1159/000015492. PMID 10773673.
Kurihara N, Menaa C, Maeda H et al. (2001). "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation". J. Biol. Chem. 276 (44): 41035–9. doi:10.1074/jbc.M100233200. PMID 11551898.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Szymkiewicz I, Destaing O, Jurdic P, Dikic I (2004). "SH3P2 in complex with Cbl and Src". FEBS Lett. 565 (1–3): 33–8. doi:10.1016/j.febslet.2004.03.100. PMID 15135048.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Li M, Meng Z, Xu Y et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of osteoclast-stimulating factor". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 1): 128–30. doi:10.1107/S1744309104031653. PMC 1952375. PMID 16508112.
Chen L, Wang Y, Wells D et al. (2006). "Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (Pt 9): 844–8. doi:10.1107/S1744309106030004. PMC 2242886. PMID 16946461.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

1x2k: Solution Structure of the SH3 Domain of Human osteoclast stimulating factor 1 (OSTF1)

1zlm: Crystal structure of the SH3 domain of human osteoclast stimulating factor