OSB

OSB may refer to:

• OSB, Amtrak station code for the Old Saybrook (Amtrak station), Connecticut, United States
• Operation Smiling Buddha, India's first test explosion of a nuclear device (1974)
• Operation Sovereign Borders, Australian border security operation
• Oracle Service Bus, enterprise service bus implementation (software networking)
• Oregon State Bar, public body regulating the legal profession in Oregon, United States
• Oriented strand board, engineered-wood product
• Orquestra Sinfônica Brasileira, the Brazilian Symphony Orchestra

Christianity

• Order of Saint Benedict, Catholic monastic order
• Order of Saint Benedict (Anglican), Anglican monastic order
• Order of Saint Benedict (Orthodox), Orthodox monastic order
• Orthodox Study Bible, Eastern Orthodox Bible in English that includes the Septuagint