OR2B6
| Olfactory receptor, family 2, subfamily B, member 6 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | OR2B6 ; OR2B1; OR2B1P; OR2B5; OR2B6P; OR5-40; OR5-41; OR6-31; dJ408B20.2 | ||||||||||||
| External IDs | MGI: 104715 HomoloGene: 40838 GeneCards: OR2B6 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26212 | 218066 | |||||||||||
| Ensembl | ENSG00000124657 | ENSMUSG00000036658 | |||||||||||
| UniProt | P58173 | Q60890 | |||||||||||
| RefSeq (mRNA) | NM_012367 | NM_146542 | |||||||||||
| RefSeq (protein) | NP_036499 | NP_666753 | |||||||||||
| Location (UCSC) | Chr 6: 27.93 – 27.93 Mb | Chr 13: 21.64 – 21.64 Mb | |||||||||||
| PubMed search | |||||||||||||
Olfactory receptor 2B6 is a protein that in humans is encoded by the OR2B6 gene.[1][2]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[2]
See also
References
- ↑ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546.
- ↑ 2.0 2.1 "Entrez Gene: OR2B6 olfactory receptor, family 2, subfamily B, member 6".
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
- OR2B6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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