o-Anisidine

o-Anisidine
Skeletal formula of o-anisidine
Ball-and-stick model of the o-anisidine molecule
Names
IUPAC name
2-Methoxyaniline
Other names
2-anisidine, ortho-aminoanisole, o-methoxyaniline, 2-methoxy-1-aminobenzene, 2-methoxyphenylamine
Identifiers
90-04-0 Yes
ChEMBL ChEMBL1612004 
ChemSpider 13860775 Yes
EC-number 201-963-1
Jmol-3D images Image
KEGG C19191 Yes
UN number 2431
Properties[1]
Molecular formula
 C7H9NO
Molar mass 123.15 g·mol−1
Appearance Yellow liquid, turns brown upon exposure to air
Density 1.0923 g/cm3
Melting point 6.2 °C (43.2 °F; 279.3 K)
Boiling point 224 °C (435 °F; 497 K)
1.5 g/100 ml
Solubility soluble in ethanol, diethyl ether, acetone, benzene
Hazards
Main hazards potential occupational carcinogen[2]
EU Index 612-035-00-4
EU classification Toxic (T)
Carc. Cat. 2
Muta. Cat. 3
R-phrases R45, R23/24/25, R68
S-phrases S53, S45
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
1
2
0
Flash point 118 °C (244 °F; 391 K) (open cup)
415 °C (779 °F; 688 K)
US health exposure limits (NIOSH):
TWA 0.5 mg/m3 [skin][2]
 : Ca TWA 0.5 mg/m3 [skin][2]
50 mg/m3[2]
Related compounds
Related compounds
 m-Anisidine
p-Anisidine
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

o-Anisidine (2-anisidine) is a yellow liquid with a melting point of -1 to 5 °C and a density of 1.09 g/cm3. The vapor pressure is 0.05 mbar at 20 °C but increases greatly with temperature. It has an aromatic smell and is well absorbed by inhalation, oral ingestion and skin contact. o-Anisidine is a very toxic agent that causes blood, enzyme and nerve damage with cyanosis and the danger of suffocation. The agent is an experimental carcinogen and is strongly suspected to be a human carcinogen also. o-Anisidine has dangerous pollutant properties for water. Non-wastewaters from the production of dyes containing o-Anisidine are listed as RCRA hazardous waste, with the code K181.[3]

References

  1. ↑ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-98. ISBN 0-8493-0462-8..
  2. ↑ 2.0 2.1 2.2 2.3 "NIOSH Pocket Guide to Chemical Hazards #0034". National Institute for Occupational Safety and Health (NIOSH).
  3. ↑ http://www.epa.gov/osw/hazard/wastetypes/wasteid/dyes/index.htm

External links