Null cell
A null cell is a large agranular lymphocyte without surface markers or membrane-associated proteins from B lymphocytes or T lymphocytes. Natural killer cells are usually null cells with surface marker CD 16 which bind to the Fc portion of the IgG, and thereby destroy it. NK-cells do immune surveillance, attack pathogens and abnormal cells. Members of null cells are NK cells, antigen dependent cytotoxic cells(ADCC), and the lymphokine activated killer(LAK)cells.
In 75% of the cases of ALL, the lymphocytes are neither B nor T-cells and are called Null cells.
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| Lymphoid/
HSC:CFU-L | |
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| | Lymphopoiesis | |
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| | Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| | Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| | Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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