Nonthrombocytopenic purpura

Nonthrombocytopenic purpura
Classification and external resources
ICD-9	287.2

Nonthrombocytopenic purpura is a type of purpura (red or purple skin discoloration) not associated with thrombocytopenia.^[1]

Examples/causes include:

Henoch-Schönlein purpura.^[2]
Hereditary hemorrhagic telangiectasia^[3]
Congenital cytomegalovirus^[1]
Meningococcemia

References

↑ 1.0 1.1 "MedlinePlus Medical Encyclopedia: Purpura". Retrieved 2009-01-06.
↑ "Evaluating the Child with Purpura - August, 2001 - American Family Physician". Retrieved 2009-01-06.
↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 650. ISBN 0-7216-0187-1.

Further reading

HORLER AR, TRUELOVE SC (March 1955). "Chronic leg ulcers in non-thrombocytopenic purpura". Br Med J 1 (4914): 635–6. doi:10.1136/bmj.1.4914.635. PMC 2061391. PMID 13230576.
MULDOON JP, BERG AM, KINNAIRD DW (November 1955). "Surgical implications of non-thrombocytopenic purpura". Ann. Surg. 142 (5): 817–23. doi:10.1097/00000658-195511000-00007. PMC 1465031. PMID 13269032.

Diseases of RBCs and megakaryocytes / MEP (D50–69,74, 280–287)

Red
blood cells

↑

Poly- cythemia	Polycythemia vera

↓

Micro-: Iron-deficiency anemia
- Plummer–Vinson syndrome

Macro-: Megaloblastic anemia
- Pernicious anemia

Hemolytic
(mostly normo-)

Hereditary	enzymopathy: G6PD glycolysis PK TI HK hemoglobinopathy: Thalassemia alpha beta delta Sickle-cell disease/trait HPFH membrane: Hereditary spherocytosis Minkowski–Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis

Acquired	Autoimmune WAHA CAD PCH membrane PNH MAHA TM HUS Drug-induced autoimmune Drug-induced nonautoimmune Hemolytic disease of the newborn

Aplastic
(mostly normo-)

MCV
MCHC
- Normochromic
- Hypochromic

Other

Coagulation/
coagulopathy

↑

Hyper- coagulability	primary: Antithrombin III deficiency Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden Prothrombin G20210A Sticky platelet syndrome acquired:Thrombocytosis essential DIC Congenital afibrinogenemia Purpura fulminans autoimmune Antiphospholipid

↓

Hypo-
coagulability

Thrombocytopenia	Thrombocytopenic purpura: ITP Evans syndrome TM TTP Upshaw Schulman syndrome Heparin-induced thrombocytopenia May–Hegglin anomaly

Platelet function	adhesion Bernard–Soulier syndrome aggregation Glanzmann's thrombasthenia platelet storage pool deficiency Hermansky–Pudlak syndrome Gray platelet syndrome

Clotting factor	Hemophilia A/VIII B/IX C/XI von Willebrand disease Hypoprothrombinemia/II XIII Dysfibrinogenemia

Index of cells from bone marrow

Description	Immune system Cells Physiology coagulation proteins granule contents colony-stimulating heme and porphyrin metabolism intermediates

Disease	Red blood cell Monocyte and granulocyte Neoplasms and cancer Histiocytosis Symptoms and signs eponymous Blood tests findings

Treatment	Transfusion Drugs thrombosis bleeding other

Pathology: hemodynamics

Decreases

Thrombus/thrombosis

Renal vein thrombosis

general:	Anemic infarct Hemorrhagic infarct

regional:	Myocardial infarction Cerebral infarction Splenic infarction Limb infarction

Increases

general	Bruise/Hematoma Petechia Purpura Ecchymosis

regional	head Epistaxis Hemoptysis Intracranial hemorrhage Hyphema Subconjunctival hemorrhage torso Hemothorax Hemopericardium Pulmonary hematoma abdomen Gastrointestinal bleeding Haemobilia Hemoperitoneum Hematocele Hematosalpinx joint Hemarthrosis

general	Anasarca Angioedema/Lymphedema Exudate/Transudate

regional	Cerebral edema Pulmonary edema Hydrothorax Ascites/hydroperitoneum Hydrosalpinx

Other

Hyperemia