Nobiletin
 | |
 | |
| Names | |
|---|---|
| IUPAC name
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one | |
| Other names
Hexamethoxyflavone | |
| Identifiers | |
478-01-3  | |
| ChemSpider | 65283  |
| |
| Jmol-3D images | Image |
| KEGG | C10112 |
| PubChem | 72344 |
| |
| Properties | |
| Molecular formula |
C21H22O8 |
| Molar mass | 402.39 g·mol−1 |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| verify (what is: /?) | |
| Infobox references | |
Nobiletin is a chemical compound. It is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine.
Potential pharmacology
Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation.[1]
Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture.[2]
References
- ↑ Henrotin, Y.; C. Lambert; D. Couchourel; C. Ripoll; E. Chiotelli (January 2011). "Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products". Osteoarthritis and Cartilage 19 (1): 1–21. doi:10.1016/j.joca.2010.10.017. PMID 21035558. Retrieved 2011-12-27.
- ↑ Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y (2008). "Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus". Eur J Pharmacol 578 (2-3): 194–200. doi:10.1016/j.ejphar.2007.09.028. PMID 17976577.
External links
- Nobiletin, phytochemicals.info
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||