Neutrophil cytosolic factor 1

PDB rendering based on 1gd5.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP

Identifiers

Symbols

NCF1 ; NCF1A; NOXO2; SH3PXD1A; p47phox

External IDs

OMIM: 608512 MGI: 97283 HomoloGene: 30964 ChEMBL: 1613743 GeneCards: NCF1 Gene

Gene ontology
Molecular function	• protein binding • electron carrier activity • superoxide-generating NADPH oxidase activity • SH3 domain binding • phosphatidylinositol binding • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• rough endoplasmic reticulum • Golgi apparatus • cytosol • extrinsic component of membrane • dendrite • phagolysosome • NADPH oxidase complex • neuronal cell body
Biological process	• response to yeast • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • respiratory burst involved in defense response • protein targeting to membrane • leukotriene metabolic process • superoxide metabolic process • apoptotic process • inflammatory response • cellular defense response • cell proliferation • superoxide anion generation • antigen processing and presentation of exogenous peptide antigen via MHC class I • innate immune response • respiratory burst • negative regulation of smooth muscle contraction • hydrogen peroxide biosynthetic process • interaction with host • oxidation-reduction process • neutrophil mediated killing of gram-positive bacterium • neutrophil mediated killing of fungus • phagosome maturation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
74.19 – 74.2 Mb

Chr 5:
134.22 – 134.23 Mb

PubMed search

Neutrophil cytosol factor 1 is a protein that in humans is encoded by the NCF1 gene.

Function

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.^[1] p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated

Interactions

Neutrophil cytosolic factor 1 has been shown to interact with:

Moesin,^[2]
Neutrophil cytosolic factor 4,^[3]^[4]^[5] and
RELA.^[6]

References

↑ "Entrez Gene: NCF1 neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)".
↑ Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW (Nov 2001). "The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain". Biochem. Biophys. Res. Commun. 289 (2): 382–8. doi:10.1006/bbrc.2001.5982. PMID 11716484. CS1 maint: Date and year (link)
↑ Lapouge K, Smith SJ, Groemping Y, Rittinger K (Mar 2002). "Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox". J. Biol. Chem. 277 (12): 10121–8. doi:10.1074/jbc.M112065200. PMID 11796733. CS1 maint: Date and year (link)
↑ Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP et al. (Mar 2001). "Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox". Biochemistry 40 (10): 3127–33. doi:10.1021/bi0028439. PMID 11258927. CS1 maint: Date and year (link)
↑ Sathyamoorthy M, de Mendez I, Adams AG, Leto TL (Apr 1997). "p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain". J. Biol. Chem. 272 (14): 9141–6. doi:10.1074/jbc.272.14.9141. PMID 9083043. CS1 maint: Date and year (link)
↑ Gu Y, Xu YC, Wu RF, Nwariaku FE, Souza RF, Flores SC et al. (May 2003). "p47phox participates in activation of RelA in endothelial cells". J. Biol. Chem. 278 (19): 17210–7. doi:10.1074/jbc.M210314200. PMID 12618429. CS1 maint: Date and year (link)

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