Neurotrophin-4

Neurotrophin 4

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1B8M, 1B98, 1HCF

Identifiers

Symbols

NTF4 ; GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5

External IDs

OMIM: 162662 MGI: 97381 HomoloGene: 4503 GeneCards: NTF4 Gene

Gene ontology
Molecular function	• growth factor activity
Cellular component	• extracellular region • endoplasmic reticulum lumen
Biological process	• ganglion mother cell fate determination • long-term memory • sensory organ boundary specification • adult locomotory behavior • epidermis development • mechanoreceptor differentiation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
49.56 – 49.57 Mb

Chr 7:
45.41 – 45.42 Mb

PubMed search

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[1]

NT-4 is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.

References

↑ "Entrez Gene: neurotrophin 4".

Childs AJ, Bayne RA, Murray AA et al. (2010). "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development.". Dev. Dyn. 239 (4): 1211–9. doi:10.1002/dvdy.22252. PMC 3410523. PMID 20175187.
Vithana EN, Nongpiur ME, Venkataraman D et al. (2010). "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population.". Mol. Vis. 16: 1640–5. PMC 2927376. PMID 20806036.
Truzzi F, Marconi A, Lotti R et al. (2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.". J. Invest. Dermatol. 128 (8): 2031–40. doi:10.1038/jid.2008.21. PMID 18305571.
Harel S, Jin S, Fisch B et al. (2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults.". Mol. Hum. Reprod. 12 (6): 357–65. doi:10.1093/molehr/gal033. PMID 16648150.
RibasÃ©s M, HervÃ¡s A, Ramos-Quiroga JA et al. (2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder.". Biol. Psychiatry 63 (10): 935–45. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783.
Chen ZY, Ieraci A, Teng H et al. (2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.". J. Neurosci. 25 (26): 6156–66. doi:10.1523/JNEUROSCI.1017-05.2005. PMC 1201519. PMID 15987945.
Pasutto F, Matsumoto T, Mardin CY et al. (2009). "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma.". Am. J. Hum. Genet. 85 (4): 447–56. doi:10.1016/j.ajhg.2009.08.016. PMC 2756554. PMID 19765683.
IbÃ¡Ã±ez CF (1996). "Neurotrophin-4: the odd one out in the neurotrophin family.". Neurochem. Res. 21 (7): 787–93. doi:10.1007/BF02532301. PMID 8873083.
Nalbandian A, Pang AL, Rennert OM et al. (2005). "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression.". Differentiation 73 (8): 385–96. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409.
Liu Y, Liu W, Crooks K et al. (2010). "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.". Am. J. Hum. Genet. 86 (3): 498–9; author reply 500. doi:10.1016/j.ajhg.2009.11.018. PMC 2833375. PMID 20215012.
GÃ¶tz R, Schartl M (1994). "The conservation of neurotrophic factors during vertebrate evolution.". Comp Biochem Physiol Pharmacol Toxicol Endocrinol 108 (1): 1–10. PMID 8061955.
GratacÃ²s M, EscaramÃs G, Bustamante M et al. (2010). "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.". J Psychiatr Res 44 (13): 834–40. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210.
Chakrabarti B, Dudbridge F, Kent L et al. (2009). "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.". Autism Research 2 (3): 157–77. doi:10.1002/aur.80. PMID 19598235.
Mizuno N, Shiba H, Inui T et al. (2008). "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells.". J. Periodontol. 79 (11): 2182–9. doi:10.1902/jop.2008.070402. PMID 18980528.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rao KN, Kaur I, Parikh RS et al. (2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population.". Invest. Ophthalmol. Vis. Sci. 51 (10): 4937–41. doi:10.1167/iovs.10-5553. PMID 20463313.
GratacÃ²s M, Costas J, de Cid R et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
Mercader JM, Saus E, AgÃ¼era Z et al. (2008). "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.". Hum. Mol. Genet. 17 (9): 1234–44. doi:10.1093/hmg/ddn013. PMID 18203754.
Walz JC, MagalhÃ£es PV, Giglio LM et al. (2009). "Increased serum neurotrophin-4/5 levels in bipolar disorder.". J Psychiatr Res 43 (7): 721–3. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579.
Prakash YS, Iyanoye A, Ay B et al. (2006). "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle.". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (3): L447–56. doi:10.1152/ajplung.00501.2005. PMID 16648236.

External links

neurotrophin 4 at the US National Library of Medicine Medical Subject Headings (MeSH)
neurotrophin 5 at the US National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery

1b98: NEUROTROPHIN 4 (HOMODIMER)

1b8m: BRAIN DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-4

1hcf: CRYSTAL STRUCTURE OF TRKB-D5 BOUND TO NEUROTROPHIN-4/5

Cell signaling: nervous tissue: neurotrophin

Trk binding

NGF
BDNF
NT-3
NT-4

GFL

Other

CNTF
GMF
IGF-1
Neuregulin (1, 2, 3, 4)
PACAP
VEGF

Index of the peripheral nervous system

Description	Anatomy Nerves cranial trigeminal cervical brachial lumbosacral plexus somatosensory spinal autonomic Physiology reflexes proteins neurotransmitters transporters Development neurotrophins

Disease	Autonomic Congenital Injury Neoplasms and cancer Other Symptoms and signs eponymous

Treatment	Procedures Local anesthetics

Neurotrophinergics

CNTF

Agonists: Axokine
CNTF

LNGF

Agonists: BDNF
NGF
NT-3
NT-4

RET

GFRα1	Agonists: GDNF

GFRα2	Agonists: Neurturin (NRTN)

GFRα3	Agonists: Artemin (ARTN)

GFRα4	Agonists: Persephin (PSPN)

Trk

TrkA	Agonists: Amitriptyline Gambogic amide NGF Antagonists: FX007

TrkB	Agonists: 3,7-DHF 3,7,8,2'-THF 4'-DMA-7,8-DHF 5,7,8-THF 7,3'-DHF 7,8-DHF 7,8,2'-THF 7,8,3'-THF Amitriptyline BDNF Deoxygedunin Diosmetin HIOC LM-22A4 N-Acetylserotonin NT-3 NT-4 TDP6 Antagonists: 3,5,7,8,3',4'-HHF ANA-12 Cyclotraxin B

TrkC	Agonists: NT-3

Neurotrophin-4

References

Further reading

External links