Neuropeptide Y receptor Y1

Rendering based on PDB 2F1U.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2F1U, 2IIL

Identifiers

Symbols

NPY1R ; NPY1-R; NPYR

External IDs

OMIM: 162641 MGI: 104963 HomoloGene: 700 IUPHAR: 305 ChEMBL: 4777 GeneCards: NPY1R Gene

Gene ontology
Molecular function	• peptide YY receptor activity • pancreatic polypeptide receptor activity • neuropeptide Y receptor activity • protein binding
Cellular component	• plasma membrane • integral component of plasma membrane
Biological process	• outflow tract morphogenesis • glucose metabolic process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • locomotory behavior • feeding behavior • regulation of blood pressure • sensory perception of pain • regulation of multicellular organism growth
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
164.25 – 164.27 Mb

Chr 8:
66.7 – 66.71 Mb

PubMed search

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[1]^[2]

Selective Ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
Peptide YY

Antagonists

Peptide

BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

BIBO-3304 (CAS# 191868-14-1)
BIBP-3226 (CAS# 159013-54-4)
PD-160,170 (CAS# 181468-88-2)

References

↑ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (Apr 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". J Biol Chem 268 (9): 6703–7. PMID 8095935.
↑ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".

External links

"Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438.
Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
Larhammar D; Blomqvist AG; Yee F et al. (1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". J. Biol. Chem. 267 (16): 10935–8. PMID 1317848.
Herzog H; Hort YJ; Ball HJ et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422.
Rose PM; Fernandes P; Lynch JS et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". J. Biol. Chem. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
Gicquiaux H; Lecat S; Gaire M et al. (2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". J. Biol. Chem. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
Sheriff S; F Qureshy A; T Chance W et al. (2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622.
Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Uddman R; Möller S; Nilsson T et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524.
Cantó Soler MV; Gallo JE; Dodds RA et al. (2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Berglund MM; Schober DA; Statnick MA et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Körner M, Waser B, Reubi JC (2005). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clin. Cancer Res. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Adhesion	ADGRG (1 2 3 4 5 6 7)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Neuropeptidergics

CGRP

Agonists: Amylin
CGRP
Pramlintide

Antagonists: BI 44370 TA
BMS-927711
CGRP (8-37)
MK-3207
Olcegepant
SB-268262
Telcagepant
Ubrogepant

Cholecystokinin

CCK_A	Agonists: Cholecystokinin CCK-4 Antagonists: Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide

CCK_B	Agonists: Cholecystokinin CCK-4 Gastrin Antagonists: CI-988 (PD-134,308) Itriglumide L-365,360 Netazepide Proglumide Spiroglumide

CRH

CRF₁	Agonists: Cortagine Corticorelin Corticotropin releasing hormone Sauvagine Stressin I Urocortin Antagonists: Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin LWH-234 NBI-27914 Pexacerfont R-121,919 TS-041 Verucerfont

CRF₂	Agonists: Corticorelin Corticotropin releasing hormone Sauvagine Urocortin Antagonists: Astressin-B

Galanin

GAL₁	Agonists: Galanin Galanin (1-15) Galanin-like peptide Galmic Galnon Antagonists: C7 Dithiepine-1,1,4,4-tetroxide Galantide (M15) M32 M35 M40 SCH-202596

GAL₂	Agonists: Galanin Galanin (1-15) Galanin (2-11) Galanin-like peptide Galmic Galnon J18 Antagonists: C7 Galantide (M15) M32 M35 M40 M871

GAL₃	Agonists: Galanin Galanin (1-15) Galmic Galnon Antagonists: C7 Galantide (M15) GalR3ant HT-2157 M32 M35 M40 SNAP-37889 SNAP-398299

MCH

MCH₁	Agonists: Melanin concentrating hormone Antagonists: ATC-0175 GW-803,430 NGD-4715 SNAP-7941 SNAP-94847

MCH₂	Agonists: Melanin concentrating hormone

Melanocortin

MC₁	Agonists: α-MSH Afamelanotide BMS-470,539 Bremelanotide Melanotan II Antagonists: Agouti signalling peptide

MC₂	Agonists: ACTH Cosyntropin Tetracosactide

MC₃	Agonists: α-MSH Bremelanotide Melanotan II

MC₄	Agonists: α-MSH Bremelanotide Melanotan II PF-00446687 THIQ Antagonists: Agouti-related peptide Unknown: Semax

MC₅	Agonists: α-MSH Melanotan II Unknown: Semax

Unsorted	Agonists: Alsactide Codactide Giractide Norleusactide Seractide Tosactide Tricosactide Tridecactide

Neuropeptide S

Agonists: Neuropeptide S
Antagonists: SHA-68

Neuropeptide Y

Y₁	Agonists: Neuropeptide Y Peptide YY Antagonists: BIBP-3226

Y₂	Agonists: Neuropeptide Y Peptide YY Antagonists: BIIE-0246

Y₄	Agonists: Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists: UR-AK49

Y₅	Agonists: Neuropeptide Y Peptide YY Antagonists: Lu AA-33810

Neurotensin

NTS₁	Agonists: Neurotensin Neuromedin N Antagonists: Meclinertant SR-142,948

NTS₂	Agonists: Neurotensin Antagonists: Levocabastine SR-142,948

Opioid

See here instead.

Orexin

OX₁	Agonists: Orexin-A Orexin-B Antagonists: ACT-335827 Almorexant Filorexant SB-334,867 SB-408,124 SB-649,868 Suvorexant

OX₂	Agonists: Orexin-A Orexin-B SB-668,875 Antagonists: ACT-335827 Almorexant EMPA Filorexant JNJ-10397049 MK-1064 SB-649,868 Suvorexant TCS-OX2-29

Oxytocin

Agonists: Aspartocin
Carbetocin
Cargutocin
Demoxytocin
Nacartocin
Oxytocin
TC OT 39
TGOT
Vasotocin (argiprestocin)
WAY-267,464
Antagonists: Atosiban
Barusiban
Epelsiban
L-368,899
L-371,257
L-372,662
OBE001
Retosiban
SSR-126,768
Tocinoic acid
WAY-162,720

Tachykinin

NK₁	Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96,345 CP-99,994 CP-122,721 Dapitant Ezlopitant Figopitant FK-888 Fosaprepitant GR-203,040 GW-597,599 HSP-117 L-733,060 L-741,671 L-743,310 L-758,298 Lanepitant LY-306,740 Maropitant Netupitant NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67,580 SDZ NKT 343 Serlopitant Telmapitant Vestipitant Vofopitant

NK₂	Agonists: Neurokinin A Antagonists: GR-159,897 Ibodutant Nepadutant Saredutant

NK₃	Agonists: Neurokinin B Antagonists: Osanetant Talnetant

Vasopressin

V_1A	Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Conivaptan Demeclocycline PF-184563 Relcovaptan RG7314 SRX246 TC OT 39 WAY-267,464

V_1B	Agonists: Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: ABT-436 Demeclocycline Nelivaptan

V₂	Agonists: Desmopressin Felypressin Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Conivaptan Demeclocycline Lixivaptan Mozavaptan Satavaptan Tolvaptan

See also: Peptidergics