Nepetalactone

Nepetalactone

Names
IUPAC name 4,7-Dimethyl-5,6,7,7a-tetrahydro-cyclopenta[c]pyran-1(4aH)-one
Identifiers
CAS Registry Number	490-10-8 Y
ChemSpider	141747 Y
InChI InChI=1S/C10H14O2/c1-6-3-4-8-7(2)5-12-10(11)9(6)8/h5-6,8-9H,3-4H2,1-2H3/t6-,8+,9+/m0/s1 Y Key: ZDKZHVNKFOXMND-NBEYISGCSA-N Y InChI=1/C10H14O2/c1-6-3-4-8-7(2)5-12-10(11)9(6)8/h5-6,8-9H,3-4H2,1-2H3
Jmol-3D images	Image
PubChem	161367
SMILES O=C1O\C=C(/[C@H]2CC[C@@H]([C@@H]12)C)C
Properties
Molecular formula	C10H14O2
Molar mass	166.22 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Nepetalactone is an organic compound, first isolated from the catnip (Nepeta cataria), which acts as a cat attractant. Nepetalactone is bicyclic monoterpenoid, i.e., it is a ten-carbon compound derived from isoprene with two fused rings: a cyclopentane and a lactone. It belongs to the class of iridoids. The structure and the effects of the compound are similar to those of valepotriates. A number of isomers of nepetalactone are known.^[1]

Nepetalactone was first reported in 1941 after it was isolated by steam distillation of catnip.^[2]

The compound is also present in the wood of tartarian honeysuckle (Lonicera tatarica), shavings of which are often used in cat toys.

Effects on animals

4aα,7α,7aα-Nepetalactone is the active isomer in Nepeta cataria and has a characteristic effect on cats. Around 80% of cats are affected;^[3] susceptibility is gene-linked. The chemical interacts as a vapor at the olfactory epithelium.^[4]

Nepetalactone has effects on some insects: it repels cockroaches and mosquitos.^[5][6]

References

1. ↑ Robert B. Bates and Carl W. Sigel (1963). "Terpenoids. Cis-trans- and trans-cis-Nepetalactones". Experientia 19: 564. 
2. ↑ Samuel M. McElvain, R. D. Bright and P. R. Johnson (1941). "The Constituents of the Volatile Oil of Catnip. I. Nepetalic Acid, Nepetalactone and Related Compounds". J. Am. Chem. Soc. 63 (6): 1558–1563. doi:10.1021/ja01851a019. 
3. ↑ Turner, Ramona (2007-05-29). "How does catnip work its magic on cats?". 
4. ↑ Hart, Benjamin L.; Leedy, Mitzi G. (July 1985). "Analysis of the catnip reaction: mediation by olfactory system, not vomeronasal organ". Behavioral and neural biology 44 (1): 38–46. doi:10.1016/S0163-1047(85)91151-3. PMID 3834921. 
5. ↑ Kingsley, Danny (September 3, 2001). "Catnip sends mozzies flying". ABC Science Online. Retrieved 2009-02-14. 
6. ↑ "The Cats Might Bite Harder Than the Mosquitoes". ENS / Ameriscan. August 28, 2001. Retrieved 2012-09-01.  (scroll down page to last article)