Nepafenac

Nepafenac
Systematic (IUPAC) name
2-amino-3-benzoylbenzeneacetamide
Clinical data
Trade names Nevanac
AHFS/Drugs.com monograph
MedlinePlus a606007
  • US: C (Risk not ruled out)
Ophthalmic
Identifiers
S01BC10
PubChem CID 151075
DrugBank DB06802 Yes
ChemSpider 133160 Yes
UNII 0J9L7J6V8C Yes
KEGG D05143 Yes
ChEBI CHEBI:75922 
ChEMBL CHEMBL1021 Yes
Chemical data
Formula C15H14N2O2
254.28 g/mol
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Nepafenac is a non-steroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution. Nepafenac is manufactured by Alcon and sold under the trade name Nevanac. It is used to treat pain and inflammation associated with cataract surgery.[1]

The usual dose is one drop, thrice a day, in each affected eye beginning one day prior to cataract surgery, continued on the day of surgery and through the first two weeks of the postoperative period.[1]

Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.[2][3] Its side effects may include decreased visual acuity, a feeling that something is in the eye, increased eye pressure or a sticky sensation, as well as other effects.[1]

References

  1. ↑ 1.0 1.1 1.2 Nepafenac monograph
  2. ↑ Drugbank: Nepafenac
  3. ↑ Lira, R. P.; Fulco, E. A.; Chaves, A.; Da Costa Pinto, F.; Arieta, F. R.; Lira, C. E. (2012). "Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: A randomized trial". Indian Journal of Ophthalmology 60 (4): 277–281. doi:10.4103/0301-4738.98705. PMC 3442462. PMID 22824596.