Nasal embryonic LHRH factor

NMDA receptor synaptonuclear signaling and neuronal migration factor

Identifiers

NSMF ; HH9; NELF

External IDs

OMIM: 608137 MGI: 1861755 HomoloGene: 10648 GeneCards: NSMF Gene

Gene ontology
Molecular function	• calcium-dependent protein binding
Cellular component	• nucleus • nuclear envelope • nuclear euchromatin • cytoplasm • postsynaptic density • membrane • nuclear matrix • cell junction • dendrite • cortical cytoskeleton • nuclear membrane • neuron projection • perikaryon • synapse • postsynaptic membrane • apical dendrite
Biological process	• positive regulation of protein dephosphorylation • regulation of neuron apoptotic process • regulation of neuronal synaptic plasticity • regulation of dendrite morphogenesis • cellular response to amino acid stimulus • cellular response to electrical stimulus • cellular response to gonadotropin stimulus • positive regulation of neuron migration
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000165802

ENSMUSG00000006476

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
140.34 – 140.35 Mb

Chr 2:
25.05 – 25.06 Mb

PubMed search

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.^[1]^[2]^[3]

References

↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Kramer PR, Wray S (Aug 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes Dev 14 (14): 1824–34. PMC 316793. PMID 10898796.
↑ "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH).". J. Hum. Genet. 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.