Naringenin-chalcone synthase

naringenin-chalcone synthase
Identifiers
EC number 2.3.1.74
CAS number 56803-04-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a naringenin-chalcone synthase (EC 2.3.1.74) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA \rightleftharpoons 4 CoA + naringenin chalcone + 3 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, naringenin chalcone, and CO2.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include chalcone synthase, flavanone synthase, 6'-deoxychalcone synthase, chalcone synthetase, DOCS, and CHS. This enzyme participates in flavonoid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes 1BI5, 1BQ6, 1CGK, 1CGZ, 1CHW, 1CML, 1D6F, 1D6H, 1D6I, 1EE0, 1I86, 1I88, 1I89, 1I8B, 1JWX, 1QLV, 1TED, 1TEE, 1U0V, 1U0W, and 2P0U.

References