Naphthylvinylpyridine
 | |
| Names | |
|---|---|
| IUPAC name
4-[(E)-2-naphthalen-1-ylethenyl]pyridine | |
| Identifiers | |
| 16375-56-7 | |
| Jmol-3D images | Image |
| PubChem | 5475238 |
| |
| Properties | |
| C17H13N | |
| Molar mass | 231.29 g/mol |
| Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
 verify (what is: / ?) | |
| Infobox references | |
Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.[1]
Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.[2][3]
References
- ↑ Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology (Squibb Institute for Medical Research) 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011.
- ↑ Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry (Department of Psychiatry and Neurobiology, Washington University School of Medicine) 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011.
- ↑ Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem (Dynamac Corporation) 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.