Naloxonazine
![]() | |
Names | |
---|---|
Other names
NIH 10894; NSC 612113, Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride | |
Identifiers | |
82824-01-9 ![]() | |
ChEMBL | ChEMBL1618376 ![]() |
ChemSpider | 7850858 ![]() |
| |
IUPHAR ligand | 1677 |
Jmol-3D images | Image |
PubChem | 9576413 |
| |
Properties | |
Molecular formula |
C38H42N4O6 |
Molar mass | 650.76 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
![]() ![]() ![]() | |
Infobox references | |
Naloxonazine is a potent irreversible mu opioid antagonist.[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.[2]
See also
- Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ) a similarly structured opioid also having two complete & mirrored morphinan carbon skeletons but which is a full agonist instead.[3]
References
- ↑ Naloxonazine dihydrochloride
- ↑ Hahn, E. F.; Pasternak, G. W. (September 1982). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences 31 (12-13): 1385–1388. doi:10.1016/0024-3205(82)90387-3. PMID 6292633. Retrieved 2011-10-18.
- ↑ Image of OM-3-MNZ