NXF2
| Nuclear RNA export factor 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NXF2 ; CT39; TAPL-2; TCP11X2 | ||||||||||||
| External IDs | OMIM: 300315 MGI: 2159343 HomoloGene: 88604 GeneCards: NXF2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56001 | 83454 | |||||||||||
| Ensembl | ENSG00000185554 | ENSMUSG00000009941 | |||||||||||
| UniProt | Q9GZY0 | Q80SZ6 | |||||||||||
| RefSeq (mRNA) | NM_001039910 | NM_001289735 | |||||||||||
| RefSeq (protein) | NP_071336 | NP_001276664 | |||||||||||
| Location (UCSC) | Chr HG1440_PATCH: 101.5 – 101.58 Mb | Chr X: 134.94 – 134.96 Mb | |||||||||||
| PubMed search | |||||||||||||
Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.[1][2][3]
Function
This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.[3]
Interactions
NXF2 has been shown to interact with NUP214.[1]
References
- ↑ 1.0 1.1 Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M et al. (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
- ↑ Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics 27 (4): 422–426. doi:10.1038/86927. PMID 11279525.
- ↑ 3.0 3.1 "Entrez Gene: NXF2 nuclear RNA export factor 2".
Further reading
- Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology 19 (12): 8616–24. PMC 84993. PMID 10567585. Vancouver style error (help)
- Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C et al. (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology 11 (18): 1381–1391. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.