NUMBL

Numb homolog (Drosophila)-like

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3F0W

Identifiers

NUMBL ; CAG3A; CTG3a; NBL; NUMB-R; NUMBLIKE; NUMBR; TNRC23

External IDs

OMIM: 604018 MGI: 894702 HomoloGene: 68413 GeneCards: NUMBL Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• cytoplasm
Biological process	• nervous system development • axonogenesis • cytokine-mediated signaling pathway • protein metabolic process • lateral ventricle development • neuroblast division in subventricular zone • adherens junction organization • positive regulation of neurogenesis • positive regulation of dendrite morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000105245

ENSMUSG00000063160

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
41.17 – 41.2 Mb

Chr 7:
27.26 – 27.28 Mb

PubMed search

Numb-like protein is a protein that in humans is encoded by the NUMBL gene.^[1]^[2]^[3]

Interactions

NUMBL has been shown to interact with MAP3K7IP2.^[4]

References

↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980.
↑ Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (Oct 1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
↑ "Entrez Gene: NUMBL numb homolog (Drosophila)-like".
↑ Ma, Qi; Zhou Li; Shi Huili; Huo Keke (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. (England) 20 (6): 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187.

Further reading

Wong WT, Schumacher C, Salcini AE et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
Zhong W, Feder JN, Jiang MM et al. (1996). "Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.". Neuron 17 (1): 43–53. doi:10.1016/S0896-6273(00)80279-2. PMID 8755477.
Zhong W, Jiang MM, Weinmaster G et al. (1997). "Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.". Development 124 (10): 1887–97. PMID 9169836.
Roncarati R, Sestan N, Scheinfeld MH et al. (2002). "The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7102–7. doi:10.1073/pnas.102192599. PMC 124535. PMID 12011466.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.