NPR3
Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.[1]
Function
The family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[1]
References
Further reading
- Fox AA, Collard CD, Shernan SK et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.". Anesthesiology 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473.
- Moffatt P, Thomas G, Sellin K et al. (2007). "Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.". J. Biol. Chem. 282 (50): 36454–62. doi:10.1074/jbc.M708596200. PMID 17951249.
- Pitzalis MV, Sarzani R, Dessì-Fulgheri P et al. (2003). "Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype.". J. Hypertens. 21 (8): 1491–6. doi:10.1097/01.hjh.0000084707.87421.35. PMID 12872042.
- Fan D, Bryan PM, Antos LK et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247.
- He Xl , Chow Dc , Martick MM, Garcia KC (2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.". Science 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490.
- Soranzo N, Rivadeneira F, Chinappen-Horsley U et al. (2009). Visscher, Peter M., ed. "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.". PLoS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- He XL, Dukkipati A, Garcia KC (2006). "Structural determinants of natriuretic peptide receptor specificity and degeneracy.". J. Mol. Biol. 361 (4): 698–714. doi:10.1016/j.jmb.2006.06.060. PMID 16870210.
- Rubattu S, Stanzione R, Di Angelantonio E et al. (2004). "Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans.". Stroke 35 (4): 814–8. doi:10.1161/01.STR.0000119381.52589.AB. PMID 15017020.
- Iemitsu M, Maeda S, Otsuki T et al. (2008). "Arterial stiffness, physical activity, and atrial natriuretic Peptide gene polymorphism in older subjects.". Hypertens. Res. 31 (4): 767–74. doi:10.1291/hypres.31.767. PMID 18633189.
- Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086.
- Gratacòs M, Costas J, de Cid R et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.
- Aoi N, Soma M, Nakayama T et al. (2004). "Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension.". Hypertens. Res. 27 (10): 711–6. doi:10.1291/hypres.27.711. PMID 15785005.
- Anand-Srivastava MB (2005). "Natriuretic peptide receptor-C signaling and regulation.". Peptides 26 (6): 1044–59. doi:10.1016/j.peptides.2004.09.023. PMID 15911072.
- Estrada K, Krawczak M, Schreiber S et al. (2009). "A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.". Hum. Mol. Genet. 18 (18): 3516–24. doi:10.1093/hmg/ddp296. PMC 2729669. PMID 19570815.
- Burgess MD, Moore KD, Carter GM et al. (2009). "C-type natriuretic peptide receptor expression in pancreatic alpha cells.". Histochem. Cell Biol. 132 (1): 95–103. doi:10.1007/s00418-009-0591-3. PMID 19352691.
- Vassalle C, Andreassi MG, Prontera C et al. (2007). "Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure.". Clin. Chem. 53 (11): 1886–90. doi:10.1373/clinchem.2007.088302. PMID 17890443.
- Lee JK, Kim HT, Cho SM et al. (2003). "Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.". J. Hum. Genet. 48 (5): 213–6. doi:10.1007/s10038-003-0011-9. PMID 12768436.
- van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325.
- He XL, Dukkipati A, Wang X, Garcia KC (2005). "A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C.". Peptides 26 (6): 1035–43. doi:10.1016/j.peptides.2004.08.035. PMID 15911071.
See also
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery |
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| | 1yk0: structure of natriuretic peptide receptor-C complexed with atrial natriuretic peptide |
| 1jdp: Crystal Structure of Hormone/Receptor Complex |
| 1yk1: structure of natriuretic peptide receptor-C complexed with brain natriuretic peptide |
| 1jdn: Crystal Structure of Hormone Receptor |
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| | G protein-coupled receptor | |
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| | Type I cytokine receptor | |
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| | Enzyme-linked receptor | |
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| Index of signal transduction |
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| | Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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