NOL3
| Nucleolar protein 3 (apoptosis repressor with CARD domain) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NOL3 ; ARC; FCM; MYP; NOP; NOP30 | ||||||||||||
| External IDs | OMIM: 605235 MGI: 1925938 HomoloGene: 31208 GeneCards: NOL3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8996 | 78688 | |||||||||||
| Ensembl | ENSG00000140939 | ENSMUSG00000014776 | |||||||||||
| UniProt | O60936 | Q9D1X0 | |||||||||||
| RefSeq (mRNA) | NM_001185057 | NM_030152 | |||||||||||
| RefSeq (protein) | NP_001171986 | NP_084428 | |||||||||||
| Location (UCSC) | Chr 16: 67.2 – 67.21 Mb | Chr 8: 105.28 – 105.28 Mb | |||||||||||
| PubMed search | |||||||||||||
Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.[1][2]
Interactions
NOL3 has been shown to interact with SFRS9[3] and Caspase 8.[1]
References
- ↑ 1.0 1.1 Koseki T, Inohara N, Chen S, Núñez G (Jun 1998). "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5156–60. doi:10.1073/pnas.95.9.5156. PMC 20230. PMID 9560245. Vancouver style error (help)
- ↑ "Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)".
- ↑ Stoss O, Schwaiger FW, Cooper TA, Stamm S (Apr 1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.
Further reading
- Stoss O, Schwaiger FW, Cooper TA, Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c". J. Biol. Chem. 274 (16): 10951–62. doi:10.1074/jbc.274.16.10951. PMID 10196175.
- Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH et al. (2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells". J. Biol. Chem. 275 (4): 2647–53. doi:10.1074/jbc.275.4.2647. PMID 10644725.
- Li PF, Li J, Müller EC, Otto A, Dietz R, von Harsdorf R (2002). "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC". Mol. Cell 10 (2): 247–58. doi:10.1016/S1097-2765(02)00600-7. PMID 12191471. Vancouver style error (help)
- Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX (2003). "Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents". Am. J. Physiol., Cell Physiol. 284 (6): C1405–10. doi:10.1152/ajpcell.00279.2002. PMID 12734105.
- Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y et al. (2004). "Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions". Mol. Cell 15 (6): 901–12. doi:10.1016/j.molcel.2004.08.020. PMID 15383280.
- Jo DG, Jun JI, Chang JW, Hong YM, Song S, Cho DH et al. (2004). "Calcium binding of ARC mediates regulation of caspase 8 and cell death". Mol. Cell. Biol. 24 (22): 9763–70. doi:10.1128/MCB.24.22.9763-9770.2004. PMC 525473. PMID 15509781.
- Wang M, Qanungo S, Crow MT, Watanabe M, Nieminen AL (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei". FEBS Lett. 579 (11): 2411–5. doi:10.1016/j.febslet.2005.03.040. PMID 15848180.
- Mercier I, Vuolo M, Madan R, Xue X, Levalley AJ, Ashton AW et al. (2005). "ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance". Cell Death Differ. 12 (6): 682–6. doi:10.1038/sj.cdd.4401631. PMID 15861191.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T et al. (2006). "Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress". Circulation 113 (9): 1203–12. doi:10.1161/CIRCULATIONAHA.105.576785. PMID 16505176.
- Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS et al. (2007). "The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant". J. Biol. Chem. 282 (8): 5522–8. doi:10.1074/jbc.M609186200. PMID 17142452.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.