NOD1

Nucleotide-binding oligomerization domain containing 1

PDB rendering based on 2b1w.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsNOD1 ; CARD4; CLR7.1; NLRC1
External IDsOMIM: 605980 MGI: 1341839 HomoloGene: 4440 IUPHAR: 1762 ChEMBL: 1293222 GeneCards: NOD1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez10392107607
EnsemblENSG00000106100ENSMUSG00000038058
UniProtQ9Y239Q8BHB0
RefSeq (mRNA)NM_006092NM_001171007
RefSeq (protein)NP_006083NP_001164478
Location (UCSC)Chr 7:
30.46 – 30.52 Mb
Chr 6:
54.92 – 54.97 Mb
PubMed search

Nucleotide-binding oligomerization domain-containing protein 1 is a protein receptor that in humans is encoded by the NOD1 gene.[1][2] It recognizes bacterial molecules and stimulates an immune reaction.

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

Further reading

References

  1. Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS (Jun 1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J Biol Chem 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
  2. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G (Jul 1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J Biol Chem 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.

External links