NLRC4

NLR family, CARD domain containing 4
Identifiers
SymbolsNLRC4 ; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF
External IDsOMIM: 606831 MGI: 3036243 HomoloGene: 10924 IUPHAR: 1782 GeneCards: NLRC4 Gene
Orthologs
SpeciesHumanMouse
Entrez58484268973
EnsemblENSG00000091106ENSMUSG00000039193
UniProtQ9NPP4Q3UP24
RefSeq (mRNA)NM_001199138NM_001033367
RefSeq (protein)NP_001186067NP_001028539
Location (UCSC)Chr 2:
32.45 – 32.49 Mb		Chr 17:
74.43 – 74.46 Mb
PubMed search

NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.[1][2]

Function

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1 (CARD4), and NOD2 (CARD15). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[2]

Interactions

NLRC4 has been shown to interact with CASP1[3][4] and NOD2.[3][4]

References

  1. ↑ Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M et al. (May 2001). "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis". Biochem Biophys Res Commun 284 (1): 77–82. doi:10.1006/bbrc.2001.4928. PMID 11374873.
  2. ↑ 2.0 2.1 "Entrez Gene: NLRC4 NLR family, CARD domain containing 4".
  3. ↑ 3.0 3.1 Damiano JS, Oliveira V, Welsh K, Reed JC (Jul 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.
  4. ↑ 4.0 4.1 Damiano JS, Stehlik C, Pio F, Godzik A, Reed JC (Jul 2001). "CLAN, a novel human CED-4-like gene". Genomics 75 (1-3): 77–83. doi:10.1006/geno.2001.6579. PMID 11472070.

Further reading

  • Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES (2001). "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.". J. Biol. Chem. 276 (30): 28309–13. doi:10.1074/jbc.C100250200. PMID 11390368.
  • Damiano JS, Stehlik C, Pio F, Godzik A, Reed JC (2001). "CLAN, a novel human CED-4-like gene.". Genomics 75 (1-3): 77–83. doi:10.1006/geno.2001.6579. PMID 11472070.
  • Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC et al. (2003). "Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.". Oncogene 22 (3): 451–5. doi:10.1038/sj.onc.1206147. PMID 12545166.
  • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.". Immunity 20 (3): 319–25. doi:10.1016/S1074-7613(04)00046-9. PMID 15030775.
  • Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016.
  • Damiano JS, Newman RM, Reed JC (2004). "Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response.". J. Immunol. 173 (10): 6338–45. doi:10.4049/jimmunol.173.10.6338. PMID 15528373.
  • Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (2005). "Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis.". Oncogene 24 (4): 627–36. doi:10.1038/sj.onc.1208201. PMID 15580302.
  • Lu C, Wang A, Wang L, Dorsch M, Ocain TD, Xu Y (2005). "Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.". Biochem. Biophys. Res. Commun. 331 (4): 1114–9. doi:10.1016/j.bbrc.2005.04.027. PMID 15882992.
  • Thalappilly S, Sadasivam S, Radha V, Swarup G (2006). "Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.". FEBS J. 273 (12): 2766–78. doi:10.1111/j.1742-4658.2006.05293.x. PMID 16817903.