NFKBIL1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

Identifiers

NFKBIL1 ; IKBL; LST1; NFKBIL

External IDs

OMIM: 601022 MGI: 1340031 HomoloGene: 3671 GeneCards: NFKBIL1 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• nucleus • cytosol
Biological process	• I-kappaB kinase/NF-kappaB cascade • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of tumor necrosis factor production • negative regulation of toll-like receptor signaling pathway • cytoplasmic sequestering of transcription factor • cellular response to lipopolysaccharide
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
31.51 – 31.53 Mb

Chr 17:
35.22 – 35.24 Mb

PubMed search

NF-kappa-B inhibitor-like protein 1 is a protein that in humans is encoded by the NFKBIL1 gene.^[1]^[2]

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function is unclear. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6.^[2]

References

↑ Albertella MR, Campbell RD (Oct 1994). "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins". Hum Mol Genet 3 (5): 793–9. doi:10.1093/hmg/3.5.793. PMID 8081366.
↑ 2.0 2.1 "Entrez Gene: NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1".

Iris FJ, Bougueleret L, Prieur S et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.". Nat. Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947.
Shiina T, Tamiya G, Oka A et al. (1998). "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region.". Genomics 47 (3): 372–82. doi:10.1006/geno.1997.5114. PMID 9480751.
Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745–54. PMID 10202016.
Allcock RJ, Christiansen FT, Price P (1999). "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15.". Immunogenetics 49 (7–8): 660–5. doi:10.1007/s002510050662. PMID 10369924.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okamoto K, Makino S, Yoshikawa Y et al. (2003). "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis". Am. J. Hum. Genet. 72 (2): 303–12. doi:10.1086/346067. PMC 379224. PMID 12509789.
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Lin CH, Cho CL, Tsai WC et al. (2006). "Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis". Immunol. Lett. 105 (2): 193–7. doi:10.1016/j.imlet.2006.03.003. PMID 16644022.
Glas J, Török HP, Tonenchi L et al. (2007). "Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes". Inflamm. Bowel Dis. 12 (7): 606–11. doi:10.1097/01.ibd.0000225346.23765.6b. PMID 16804398.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Koch W, Hoppmann P, Michou E et al. (2007). "Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans". Hum. Mol. Genet. 16 (15): 1821–7. doi:10.1093/hmg/ddm130. PMID 17517687.
Ramasawmy R, Faé KC, Cunha-Neto E et al. (2007). "Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals". Mol. Immunol. 45 (1): 283–8. doi:10.1016/j.molimm.2007.04.015. PMID 17544510.
Kariz S, Milutinović A, Bregar D et al. (2007). "The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes". Collegium antropologicum 31 (2): 503–7. PMID 17847930.

NFKBIL1

References

Further reading