NEUROG2
| Neurogenin 2 | |||
|---|---|---|---|
| Identifiers | |||
| Symbols | NEUROG2 ; Atoh4; Math4A; NGN2; bHLHa8; ngn-2 | ||
| External IDs | OMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2 Gene | ||
| Orthologs | |||
| Species | Human | Mouse | |
| Entrez | 63973 | 11924 | |
| Ensembl | ENSG00000178403 | ENSMUSG00000027967 | |
| UniProt | Q9H2A3 | P70447 | |
| RefSeq (mRNA) | NM_024019 | NM_009718 | |
| RefSeq (protein) | NP_076924 | NP_033848 | |
| Location (UCSC) | Chr 4: 113.43 – 113.44 Mb | Chr 3: 127.63 – 127.64 Mb | |
| PubMed search | |||
Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[1]
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[2]
References
- ↑ "Entrez Gene: neurogenin 2".
- ↑ Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature 455 (7209): 114–8. doi:10.1038/nature07198. PMID 18690213.
Further reading
- Gradwohl G, Fode C, Guillemot F (1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.
- Simmons AD, Horton S, Abney AL, Johnson JE (2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers.". Dev. Biol. 229 (2): 327–39. doi:10.1006/dbio.2000.9984. PMID 11203697.
- Kumar M, Bagchi B, Gupta SK et al. (2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells.". Stem Cells Dev. 16 (4): 667–81. doi:10.1089/scd.2006.0115. PMID 17784840.
- Deng S, Deng H, Le W et al. (2009). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.". Neurosci. Lett. 468 (3): HASH(0x24e91e0). doi:10.1016/j.neulet.2009.10.078. PMID 19879328.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Park CH, Kang JS, Yoon EH et al. (2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. doi:10.1016/j.febslet.2008.01.018. PMID 18242186.
- Fode C, Gradwohl G, Morin X et al. (1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron 20 (3): 483–94. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123.
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