NEO1
| Neogenin 1 | |||||||||||||
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 PDB rendering based on 1x5f. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NEO1 ; IGDCC2; NGN; NTN1R2 | ||||||||||||
| External IDs | OMIM: 601907 MGI: 1097159 HomoloGene: 1870 GeneCards: NEO1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4756 | 18007 | |||||||||||
| Ensembl | ENSG00000067141 | ENSMUSG00000032340 | |||||||||||
| UniProt | Q92859 | Q7TQG5 | |||||||||||
| RefSeq (mRNA) | NM_001172623 | NM_001042752 | |||||||||||
| RefSeq (protein) | NP_001166094 | NP_001036217 | |||||||||||
| Location (UCSC) | Chr 15: 73.34 – 73.6 Mb | Chr 9: 58.87 – 59.04 Mb | |||||||||||
| PubMed search | |||||||||||||
Neogenin is a protein that in humans is encoded by the NEO1 gene.[1][2]
Interactions
NEO1 has been shown to interact with PTK2.[3]
References
- ↑ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
- ↑ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
- ↑ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ et al. (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.
Further reading
- Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer.". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578.
- Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.". Cell 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
- Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR et al. (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23.". Genomics 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
- Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.". J. Neurosci. 19 (12): 4938–47. PMID 10366627.
- Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis.". Dev. Cell 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
- Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.". Oncogene 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
- Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P et al. (2004). "RGM and its receptor neogenin regulate neuronal survival.". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591.
- Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ et al. (2005). "Focal adhesion kinase in netrin-1 signaling.". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.
- Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ et al. (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer.". BMC Cancer 5: 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219.
- Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
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