NDEL1

NudE neurodevelopment protein 1-like 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2V66

Identifiers

Symbols

NDEL1 ; EOPA; MITAP1; NDE1L1; NDE2; NUDEL

External IDs

OMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1 Gene

Gene ontology
Molecular function	• protein binding • microtubule binding • alpha-tubulin binding • beta-tubulin binding • oligopeptidase activity
Cellular component	• kinetochore • condensed chromosome kinetochore • nuclear envelope • nucleolus • cytoplasm • centrosome • spindle • cytosol • kinesin complex • microtubule • axon • cell leading edge • cell body • neurofilament cytoskeleton
Biological process	• microtubule cytoskeleton organization • mitotic cell cycle • neuron migration • inner cell mass cell proliferation • proteolysis • chromosome segregation • retrograde axon cargo transport • cerebral cortex radially oriented cell migration • central nervous system neuron axonogenesis • activation of Cdc42 GTPase activity • positive regulation of axon extension • vesicle transport along microtubule • positive regulation of axon regeneration • nuclear envelope disassembly • centrosome localization • neurofilament cytoskeleton organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
8.32 – 8.39 Mb

Chr 11:
68.82 – 68.87 Mb

PubMed search

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[1]^[2]^[3]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

Interactions

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[1] YWHAE,^[4] PAFAH1B1^[1]^[4] and DISC1.^[5]^[6]

References

↑ 1.0 1.1 1.2 Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Feb 2001). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260.
↑ Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Feb 2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259.
↑ 3.0 3.1 "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1".
↑ 4.0 4.1 Toyo-oka, Kazuhito; Shionoya Aki, Gambello Michael J, Cardoso Carlos, Leventer Richard, Ward Heather L, Ayala Ramses, Tsai Li-Huei, Dobyns William, Ledbetter David, Hirotsune Shinji, Wynshaw-Boris Anthony (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. (United States) 34 (3): 274–85. doi:10.1038/ng1169. ISSN 1061-4036. PMID 12796778.
↑ Morris, Jill A; Kandpal Geeta; Ma Lei; Austin Christopher P (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986.
↑ Ozeki, Yuji; Tomoda Toshifumi, Kleiderlein John, Kamiya Atsushi, Bord Lyuda, Fujii Kumiko, Okawa Masako, Yamada Naoto, Hatten Mary E, Snyder Solomon H, Ross Christopher A, Sawa Akira (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (1): 289–94. doi:10.1073/pnas.0136913100. ISSN 0027-8424. PMC 140954. PMID 12506198.

Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Feng Y, Olson EC, Stukenberg PT et al. (2001). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.". Neuron 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ozeki Y, Tomoda T, Kleiderlein J et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.
Yan X, Li F, Liang Y et al. (2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.". Mol. Cell. Biol. 23 (4): 1239–50. doi:10.1128/MCB.23.4.1239-1250.2003. PMC 141156. PMID 12556484.
Cardoso C, Leventer RJ, Ward HL et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
Toyo-oka K, Shionoya A, Gambello MJ et al. (2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandon NJ, Handford EJ, Schurov I et al. (2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.". Mol. Cell. Neurosci. 25 (1): 42–55. doi:10.1016/j.mcn.2003.09.009. PMID 14962739.
Liang Y, Yu W, Li Y et al. (2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.". J. Cell Biol. 164 (4): 557–66. doi:10.1083/jcb.200308058. PMC 2171987. PMID 14970193.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tarricone C, Perrina F, Monzani S et al. (2005). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.". Neuron 44 (5): 809–21. doi:10.1016/j.neuron.2004.11.019. PMID 15572112.
Hayashi MA, Portaro FC, Bastos MF et al. (2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.". Proc. Natl. Acad. Sci. U.S.A. 102 (10): 3828–33. doi:10.1073/pnas.0500330102. PMC 553309. PMID 15728732.
Guerreiro JR, Winnischofer SM, Bastos MF et al. (2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation.". Biochim. Biophys. Acta 1730 (1): 77–84. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.

NDEL1

Interactions

References

Further reading