NCR2

Natural cytotoxicity triggering receptor 2

PDB rendering based on 1hkf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsNCR2 ; CD336; LY95; NK-p44; NKP44; dJ149M18.1
External IDsOMIM: 604531 HomoloGene: 130365 GeneCards: NCR2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez9436n/a
EnsemblENSG00000096264n/a
UniProtO95944n/a
RefSeq (mRNA)NM_001199509n/a
RefSeq (protein)NP_001186438n/a
Location (UCSC)Chr 6:
41.3 – 41.32 Mb		n/a
PubMed searchn/a

Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene.[1][2] NCR2 has also been designated as CD336 (cluster of differentiation 336).

References

  1. ↑ Cantoni C, Bottino C, Vitale M, Pessino A, Augugliaro R, Malaspina A, Parolini S, Moretta L, Moretta A, Biassoni R (Jun 1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J Exp Med 189 (5): 787–96. doi:10.1084/jem.189.5.787. PMC 2192947. PMID 10049942.
  2. ↑ "Entrez Gene: NCR2 natural cytotoxicity triggering receptor 2".

Further reading

  • Hershkovitz O, Jivov S, Bloushtain N et al. (2007). "Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.". Biochemistry 46 (25): 7426–36. doi:10.1021/bi7000455. PMID 17536787.
  • Forte P, Lilienfeld BG, Baumann BC, Seebach JD (2005). "Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D.". J. Immunol. 175 (8): 5463–70. doi:10.4049/jimmunol.175.8.5463. PMID 16210654.
  • Fuchs A, Cella M, Kondo T, Colonna M (2005). "Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44.". Blood 106 (6): 2076–82. doi:10.1182/blood-2004-12-4802. PMID 15941912.
  • Poggi A, Massaro AM, Negrini S et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors.". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
  • Nowbakht P, Ionescu MC, Rohner A et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias.". Blood 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
  • Campbell KS, Yusa S, Kikuchi-Maki A, Catina TL (2004). "NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence.". J. Immunol. 172 (2): 899–906. doi:10.4049/jimmunol.172.2.899. PMID 14707061.
  • Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Cantoni C, Ponassi M, Biassoni R et al. (2004). "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.". Structure 11 (6): 725–34. doi:10.1016/S0969-2126(03)00095-9. PMID 12791260.
  • Augugliaro R, Parolini S, Castriconi R et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells.". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048.
  • Eapen BR (2003). "A new insight into the pathogenesis of Reiter's syndrome using bioinformatics tools.". Int. J. Dermatol. 42 (3): 242–3. doi:10.1046/j.1365-4362.2003.01704.x. PMID 12653925.
  • Allcock RJ, Barrow AD, Forbes S et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956.
  • Cantoni C, Ponassi M, Biassoni R et al. (2003). "Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44.". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 10 Pt 2): 1843–5. doi:10.1107/S0907444902012325. PMID 12351833.

External links