NCOA4
| Nuclear receptor coactivator 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NCOA4 ; ARA70; ELE1; PTC3; RFG | ||||||||||||
| External IDs | OMIM: 601984 MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8031 | 27057 | |||||||||||
| Ensembl | ENSG00000138293 | ENSMUSG00000056234 | |||||||||||
| UniProt | Q13772 | E9PVM8 | |||||||||||
| RefSeq (mRNA) | NM_001145260 | NM_001033988 | |||||||||||
| RefSeq (protein) | NP_001138732 | NP_001029160 | |||||||||||
| Location (UCSC) | Chr 10: 51.57 – 51.59 Mb | Chr 14: 32.16 – 32.18 Mb | |||||||||||
| PubMed search | |||||||||||||
Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]
Interactions
NCOA4 has been shown to interact with:
- Androgen receptor,[2][4][5][6][7][8][9][10][11] and
- Peroxisome proliferator-activated receptor gamma[12]
See also
References
- ↑ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261.
- ↑ 2.0 2.1 Yeh S, Chang C (July 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
- ↑ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4".
- ↑ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (January 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
- ↑ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
- ↑ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
- ↑ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
- ↑ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
- ↑ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
- ↑ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
- ↑ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
- ↑ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
External links
Further reading
- Minoletti F, Butti MG, Coronelli S et al. (1995). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.". Genes Chromosomes Cancer 11 (1): 51–7. doi:10.1002/gcc.2870110108. PMID 7529046.
- Jhiang SM, Smanik PA, Mazzaferri EL (1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma.". Cancer Lett. 78 (1-3): 69–76. doi:10.1016/0304-3835(94)90033-7. PMID 8180971.
- Bongarzone I, Butti MG, Coronelli S et al. (1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.". Cancer Res. 54 (11): 2979–85. PMID 8187085.
- Bongarzone I, Butti MG, Fugazzola L et al. (1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.". Genomics 42 (2): 252–9. doi:10.1006/geno.1997.4685. PMID 9192845.
- Miyamoto H, Yeh S, Wilding G, Chang C (1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
- Alen P, Claessens F, Schoenmakers E et al. (1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.". Mol. Endocrinol. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
- Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
- Yeh S, Lin HK, Kang HY et al. (1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
- Heinlein CA, Ting HJ, Yeh S, Chang C (1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.". J. Biol. Chem. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
- Gao T, Brantley K, Bolu E, McPhaul MJ (1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays.". Mol. Endocrinol. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Lin HK, Yeh S, Kang HY, Chang C (2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
- Basolo F, Giannini R, Monaco C et al. (2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.". Am. J. Pathol. 160 (1): 247–54. doi:10.1016/S0002-9440(10)64368-4. PMC 1867131. PMID 11786418.
- Zhou ZX, He B, Hall SH et al. (2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR).". Mol. Endocrinol. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
- Thin TH, Kim E, Yeh S et al. (2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.". J. Biol. Chem. 277 (39): 36499–508. doi:10.1074/jbc.M202824200. PMID 12068007.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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